{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T18:40:50Z","timestamp":1697654450114},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,6,29]],"date-time":"2006-06-29T00:00:00Z","timestamp":1151539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We report the case of an infant affected with congenital systemic juvenile xanthogranuloma scheduled for central venous access system implantation (Port\u2010a\u2010Cath<jats:sup>TM<\/jats:sup>) and a liver and bone marrow biopsy. The patient had impaired liver function, thrombocytopenia, and coagulopathy which was refractory to daily fresh\u2010frozen plasma and platelet infusions: 80\u2003<jats:italic>\u03bc<\/jats:italic>g\u00b7kg<jats:sup>\u22121<\/jats:sup> dose<jats:sup>\u22121<\/jats:sup> of recombinant factor VIIa (rFVIIa) was administered i.v. every 2\u2003h starting 30\u2003min before the procedure and ending 6\u2003h afterwards. Very minor bleeding was observed during the procedure. In conclusion, rFVIIa therapy was effective as prophylaxis for both invasive procedures in this patient with a coagulopathy which was refractory to other different therapies.<\/jats:p>","DOI":"10.1111\/j.1460-9592.2006.02009.x","type":"journal-article","created":{"date-parts":[[2006,6,30]],"date-time":"2006-06-30T00:11:58Z","timestamp":1151626318000},"page":"974-976","source":"Crossref","is-referenced-by-count":8,"title":["Prophylactic recombinant factor VIIa administration to an infant with congenital systemic juvenile xanthogranuloma"],"prefix":"10.1111","volume":"16","author":[{"given":"JESUS","family":"DE SANTIAGO","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ERNESTO","family":"MARTINEZ\u2010GARCIA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JORGE","family":"GIRON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CONCEPCI\u00d3N","family":"SALCEDO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANTONIO","family":"P\u00c9REZ\u2010GALLARDO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,6,29]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199709)29:3<157::AID-MPO1>3.0.CO;2-C"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200305000-00003"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(96)70247-0"},{"key":"e_1_2_4_5_2","first-page":"583","volume-title":"Schiff's Diseases of the Liver","author":"Rutherford CJ","year":"1999"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2003.11.022"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200309000-00013"},{"key":"e_1_2_4_8_2","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1055\/s-0037-1615667","article-title":"Combined fresh frozen plasma with recombinant factor VIIa in restoring hemostasis for invasive procedures in children with liver diseases","volume":"85","author":"Chuansumrit A","year":"2001","journal-title":"Thromb Haemost"},{"key":"e_1_2_4_9_2","first-page":"159","article-title":"Clinical experience with recombinant factor VIIa in patients with thrombocytopenia","volume":"26","author":"Kristensen J","year":"1997","journal-title":"Haemostasis"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.11.3951"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2003.11.006"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2005.11.025"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2004.00759.x"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc3781"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2001.00478.x"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.29.11.971"}],"container-title":["Pediatric Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1460-9592.2006.02009.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1460-9592.2006.02009.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T08:11:08Z","timestamp":1696925468000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1460-9592.2006.02009.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6,29]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1111\/j.1460-9592.2006.02009.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1460-9592.2006.02009.x","archive":["Portico"],"relation":{},"ISSN":["1155-5645","1460-9592"],"issn-type":[{"value":"1155-5645","type":"print"},{"value":"1460-9592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6,29]]}}}