{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T21:06:30Z","timestamp":1760043990677},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We present the analgesic management of a 4\u2010year\u2010old child who suffered from severe abdominal and leg pain during his first vaso\u2010occlusive crisis with sickle cell disease, diagnosed as <jats:italic>\u03b2<\/jats:italic>\/S disease when he was 1\u2003year old. His mother and father were carriers of <jats:italic>\u03b2<\/jats:italic>\u2010thalassemia and hemoglobin S, respectively. He had an upper respiratory tract infection in which a vaso\u2010occlusive crisis was precipitated. On admission to hospital, fever, severe abdominal and leg pain were noted. Hemoglobin was 4\u2003g\u00b7dl<jats:sup>\u22121<\/jats:sup> with accompanying prominent reticulocytosis and acute spleen enlargement. These findings indicated a sequestration crisis as well as vaso\u2010occlusive disease. He was transfused with packed red cells. Paracetamol (40\u201360\u2003mg\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7day<jats:sup>\u22121<\/jats:sup>) and ibuprofen (20\u2003mg\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7day<jats:sup>\u22121<\/jats:sup>) were administered to relieve pain. The child experienced moderate to severe pain (Oucher score 60\u201380) despite nonopioid analgesics, so a tramadol infusion (0.25\u2003mg\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7h<jats:sup>\u22121<\/jats:sup>) was started. During the tramadol infusion no morphine was required, the intensity of pain gradually decreased (Oucher score 20) and the child was able to move his legs. At the end of 3\u2003days splenomegaly regressed, no fever and pain were observed and the infusion was stopped. In conclusion, tramadol infusion i.v. (0.25\u2003mg\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7h<jats:sup>\u22121<\/jats:sup>) combined with nonopioids was effective to relieve moderate to severe pain due to vaso\u2010occlusive crisis and can be recommended before using morphine in a pediatric sickle cell crisis.<\/jats:p>","DOI":"10.1111\/j.1460-9592.2006.02030.x","type":"journal-article","created":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T15:27:01Z","timestamp":1153409221000},"page":"84-86","source":"Crossref","is-referenced-by-count":17,"title":["Tramadol infusion for the pain management in sickle cell disease: a case report"],"prefix":"10.1111","volume":"17","author":[{"given":"ELVAN","family":"ERHAN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MEHMET T.","family":"INAL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YESIM","family":"AYDINOK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CAN","family":"BALKAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"IBRAHIM","family":"YEGUL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_4_2_2","first-page":"799","volume-title":"Bon\u0131ca's Management of Pain","author":"Goldschneider KR","year":"2001"},{"key":"e_1_2_4_3_2","first-page":"295","volume-title":"Practical Management of Pain","author":"Desparmet\u2010Sheridan JF","year":"2000"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199107043250103"},{"key":"e_1_2_4_5_2","first-page":"328","article-title":"Multidisciplinary approach to pain management in sickle cell disease","volume":"4","author":"Vichinsky EP","year":"1982","journal-title":"Am J Pediatr Hematol Oncol"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04193.x"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(83)80258-3"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.2165\/00128072-200305040-00003"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200060010-00008"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1191\/096813098668122984"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.2003.00983.x"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003643-199907000-00002"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001200050136"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2346.2000.00729.x"},{"key":"e_1_2_4_15_2","first-page":"1389","article-title":"A pilot study on the efficacy of ketorolac plus tramadol infusion combined with erythrocytapheresis in the management of acute severe vaso\u2010occlusive crises and sickle cell pain","volume":"89","author":"De Franceschi L","year":"2004","journal-title":"Haematologica"}],"container-title":["Pediatric Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1460-9592.2006.02030.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1460-9592.2006.02030.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T03:23:22Z","timestamp":1696908202000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1460-9592.2006.02030.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,19]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1111\/j.1460-9592.2006.02030.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1460-9592.2006.02030.x","archive":["Portico"],"relation":{},"ISSN":["1155-5645","1460-9592"],"issn-type":[{"value":"1155-5645","type":"print"},{"value":"1460-9592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,19]]}}}