{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:10:55Z","timestamp":1782601855501,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,8,14]],"date-time":"2006-08-14T00:00:00Z","timestamp":1155513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> The aims of the present study were to determine the tracheal intubating conditions, onset time, duration of action, and hemodynamic responses following the administration of cisatracurium 0.15\u2003mg\u00b7kg<jats:sup>\u22121<\/jats:sup> to infants and children.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> One hundred and eighty\u2010one infants and children aged 1\u2003month to 12\u2003years were randomized to two groups to receive anesthesia with nitrous oxide\u2013oxygen\u2013halothane (group H) or nitrous oxide\u2013oxygen\u2013thiopental\u2010fentanyl (group TF). Intubation conditions were assessed 120\u2003s after cisatracurium administration using a 4\u2010part scale. Neuromuscular transmission was monitored by recording the evoked compound electromyogram of the adductor pollicis.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The proportion of patients with excellent or good intubating conditions was similar in both groups (88 of 90, 98% in group H; 85 of 90, 94% in group TF). However, there was a significantly greater proportion of excellent intubating conditions in group H (79 of 90, 88%) compared with group TF (65 of 90, 72%) (<jats:italic>P<\/jats:italic>\u2003=\u20030.01) and recovery time was significantly longer in group H compared with group TF (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). There was also a higher proportion of excellent intubating conditions in infants compared with older subjects (<jats:italic>P<\/jats:italic>\u2003=\u20030.02) and a shorter onset time (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001) and longer recovery time (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001) in younger compared with older patients. Changes in heart rate and arterial pressure were negligible 1\u2003min following the cisatracurium administration.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Cisatracurium 0.15\u2003mg\u00b7kg<jats:sup>\u22121<\/jats:sup> produces acceptable intubating conditions at 120\u2003s in the great majority of infants and children. Anesthesia background and age have significant effects on intubating conditions and duration of action of cisatracurium.<\/jats:p>","DOI":"10.1111\/j.1460-9592.2006.02042.x","type":"journal-article","created":{"date-parts":[[2006,8,14]],"date-time":"2006-08-14T13:31:26Z","timestamp":1155562286000},"page":"113-120","source":"Crossref","is-referenced-by-count":14,"title":["Tracheal intubating conditions and pharmacodynamics following cisatracurium in infants and children undergoing halothane and thiopental\u2010fentanyl anesthesia"],"prefix":"10.1111","volume":"17","author":[{"given":"GEORGE\u00a0H.","family":"MEAKIN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"OLLI 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