{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T23:49:40Z","timestamp":1782949780147,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,10,17]],"date-time":"2006-10-17T00:00:00Z","timestamp":1161043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background<\/jats:bold> :\u2002A few previous studies have suggested the efficacy of i.v. ketamine for postoperative pain relief in children after adenotonsillectomy, but none has investigated the efficacy of peritonsillar infiltration of ketamine in these children.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold> :\u2002This randomized, placebo\u2010controlled study evaluated the effects of peritonsillar infiltration of ketamine in children undergoing adenotonsillectomy. Ninety ASA I\u2010II children were randomized three groups of 30 each. Group I received: 2\u2003ml i.v. saline, group II received i.v. ketamine (0.5\u2003mg\u00b7kg<jats:sup>\u22121<\/jats:sup>) and group III received a local peritonsillar infiltration of ketamine (0.5\u2003mg\u00b7kg<jats:sup>\u22121<\/jats:sup>). All medications were 2\u2003ml in volume which was applied 1\u2003ml per tonsil 3\u2003min prior to tonsillectomy. Modified Hannallah pain scale [observational pain scores (OPS)], nausea, vomiting, bleeding, rescue analgesia, sedation and Aldrete scores were recorded at first, 15th, 30th and 60th min postoperatively. Patients were interviewed on the day after surgery to assess the postoperative pain, nightmares, hallucinations, vomiting and bleeding.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> :\u2002Group I had higher OPS scores than group II and group III. Group II and group III had comparable scores, which were not statistically significant (<jats:italic>P<\/jats:italic>\u2003&gt;\u20030.05). Group II had higher sedation score at 15th min (<jats:italic>P<\/jats:italic>\u2003=\u20030.015). Thirty\u2010two children, 19 of whom were in group I had rescue analgesia in postanesthesia care unit (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05) and the time to first analgesic requirement was significantly shorter in group I than the other groups (<jats:italic>P<\/jats:italic>\u2003=\u20030.006). Group II and group III also had less pain than group I at home (<jats:italic>P<\/jats:italic>\u2003=\u20030.023).<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold> :\u2002Low dose ketamine given i.v. or by peritonsillar infiltration perioperatively provides efficient pain relief without side\u2010effects in children undergoing adenotonsillectomy.<\/jats:p>","DOI":"10.1111\/j.1460-9592.2006.02095.x","type":"journal-article","created":{"date-parts":[[2006,10,17]],"date-time":"2006-10-17T15:21:30Z","timestamp":1161098490000},"page":"263-269","source":"Crossref","is-referenced-by-count":63,"title":["The efficacy of intravenous or peritonsillar infiltration of ketamine for postoperative pain relief in children following adenotonsillectomy<sup>1<\/sup>"],"prefix":"10.1111","volume":"17","author":[{"given":"DIDEM","family":"DAL","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NALAN","family":"CELEBI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ELVAN GAYE","family":"ELVAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"VAROL","family":"CELIKER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ULKU","family":"AYPAR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,10,17]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.2003.01049.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200306000-00030"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-200301000-00015"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-6576.2001.450820.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/014556139807700515"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(00)70103-3"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199608000-00012"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2003.11.038"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.2001.00676.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2004.00399.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2004.01223.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(96)12922-0"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198706000-00023"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.93.5.784"},{"key":"e_1_2_6_16_2","first-page":"232","article-title":"Midazolam\u2010opioid combination and postoperative upper airway obstruction in children","volume":"2","author":"Negus BH","year":"1995","journal-title":"Anaesth Intensive Care"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-6576.2000.440312.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.1995.tb00275.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1996.tb15063.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1996.tb05552.x"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X9402200606"},{"key":"e_1_2_6_22_2","first-page":"142","article-title":"Tonsillectomy and the value of peritonsillar infiltrations","volume":"36","author":"Costas\u2010Gastiaburo LA","year":"1998","journal-title":"S Afr J Surg"}],"container-title":["Pediatric Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1460-9592.2006.02095.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1460-9592.2006.02095.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T06:47:35Z","timestamp":1697266055000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1460-9592.2006.02095.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,17]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["10.1111\/j.1460-9592.2006.02095.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1460-9592.2006.02095.x","archive":["Portico"],"relation":{},"ISSN":["1155-5645","1460-9592"],"issn-type":[{"value":"1155-5645","type":"print"},{"value":"1460-9592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,17]]}}}