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The P450 CYP3A4 enzyme is responsible for the major metabolic <jats:italic>N\u2010<\/jats:italic>dealkylation pathway. Enzyme activity is reduced in neonates but the maturation of sufentanil clearance is not described. The free active fraction is affected by age because of the reduced \u03b1<jats:sub>1<\/jats:sub>\u2010acid glycoprotein plasma concentrations in neonates. Intranasal administration of sufentanil is a possible option for premedication, procedural sedation and analgesia in children, as this option has been found to be safe and effective. Studies concerning the pharmacokinetics and dynamics of sufentanil administered as a bolus or continuous infusion in children are few.<\/jats:p>","DOI":"10.1111\/j.1460-9592.2010.03411.x","type":"journal-article","created":{"date-parts":[[2010,9,17]],"date-time":"2010-09-17T04:19:51Z","timestamp":1284697191000},"page":"274-279","source":"Crossref","is-referenced-by-count":48,"title":["Aspects of pharmacokinetics and pharmacodynamics of sufentanil in pediatric practice"],"prefix":"10.1111","volume":"21","author":[{"given":"Stefan","family":"Lundeberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Roelofse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,9,16]]},"reference":[{"issue":"1","key":"e_1_2_4_2_2","first-page":"106","article-title":"Continuous epidural of Sufentanil after caesarean section: concentration in 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