{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T06:34:36Z","timestamp":1774506876438,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,4,28]],"date-time":"2011-04-28T00:00:00Z","timestamp":1303948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective:\u2002<\/jats:bold> To determine minimum alveolar concentration (MAC) of sevoflurane for maintaining bispectral index (BIS) below 50 (MAC<jats:sub>BIS50<\/jats:sub>) in children.<\/jats:p><jats:p><jats:bold>Background:\u2002<\/jats:bold> MAC<jats:sub>BIS50<\/jats:sub> of sevoflurane in adults was reported to be 0.97%, which has not been elucidated in children.<\/jats:p><jats:p><jats:bold>Methods\/Materials:\u2002<\/jats:bold> Twenty children, American Society of Anesthesiologists physical status I or II, aged 1\u20138, were induced and anesthetized with sevoflurane in oxygen. After tracheal intubation, we started maintenance of anesthesia with endtidal sevoflurane concentrations of 2.6%. The endtidal sevoflurane concentration at which BIS was measured was predetermined by the up\u2010down method (with 0.2% as a step size). After 10\u2003min at predetermined endtidal sevoflurane concentrations, BIS was measured for 1\u2003min. MAC<jats:sub>BIS50<\/jats:sub> was determined using Dixon\u2019s up\u2010down method and probit test.<\/jats:p><jats:p><jats:bold>Result:\u2002<\/jats:bold> MAC<jats:sub>BIS50<\/jats:sub> of sevoflurane was 2.83% (95% confidence intervals: 2.70\u20133.14) in children.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> MAC<jats:sub>BIS50<\/jats:sub> of sevoflurane in children was calculated to be three times as high as in adults. This indicates that high endtidal sevoflurane concentration is required to suppress electroencephalogram activity in children.<\/jats:p>","DOI":"10.1111\/j.1460-9592.2011.03602.x","type":"journal-article","created":{"date-parts":[[2011,4,28]],"date-time":"2011-04-28T10:07:30Z","timestamp":1303985250000},"page":"1124-1127","source":"Crossref","is-referenced-by-count":26,"title":["Minimum alveolar concentrations of sevoflurane for maintaining bispectral index below 50 in children"],"prefix":"10.1111","volume":"21","author":[{"given":"Shouhei","family":"Tsuruta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Satsumae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taro","family":"Mizutani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Inomata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeru","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,4,28]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aei140"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-200004000-00018"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aei196"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aei247"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2006.02083.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0265021508004845"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e318181ef88"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199704000-00014"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aen382"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198703000-00006"},{"key":"e_1_2_7_12_2","first-page":"251","volume-title":"Statistics in Endocrinology","author":"Dixon W","year":"1967"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2008.02664.x"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199905000-00019"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000278117.31134.34"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199311000-00024"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199401000-00016"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199404000-00014"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199812000-00010"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200008000-00012"},{"key":"e_1_2_7_21_2","first-page":"32","volume-title":"Pediatric Anesthesia: Principles and Practice","author":"Prashant J","year":"2002"}],"container-title":["Pediatric Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1460-9592.2011.03602.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1460-9592.2011.03602.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T11:51:32Z","timestamp":1697284292000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1460-9592.2011.03602.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,28]]},"references-count":20,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["10.1111\/j.1460-9592.2011.03602.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1460-9592.2011.03602.x","archive":["Portico"],"relation":{},"ISSN":["1155-5645","1460-9592"],"issn-type":[{"value":"1155-5645","type":"print"},{"value":"1460-9592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,28]]}}}