{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:21:27Z","timestamp":1780478487972,"version":"3.54.1"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,9,20]],"date-time":"2011-09-20T00:00:00Z","timestamp":1316476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> Acquired deficiency of FXIII because of perioperative hemodilution has been described several times in adults; however, data in children are scarce. We performed a prospective observational trial to evaluate the intraoperative course of FXIII in children undergoing elective major surgery.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Blood samples were repeatedly taken from 46 children aged 0.3\u201316\u2003years undergoing major surgery. Concentrations of FXIII and fibrinogen, thrombelastometry by ROTEM<jats:sup>\u00ae<\/jats:sup>, and cell count were assessed intraoperatively.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> A significant decrease in FXIII concentration (median 60%; IQR 49\u201369%) was already noted at beginning of surgical procedures, while most ROTEM<jats:sup>\u00ae<\/jats:sup> traces remain unchanged. FXIII levels further deteriorated intraoperatively to minimal levels of 33% (15\u201361%). Lowest intraoperative clot strength (ExTEM) was 44\u2003mm (34\u201350\u2003mm), and fibrinogen plasma levels decreased to minimal levels of 130\u2003mg\u00b7dl<jats:sup>\u22121<\/jats:sup> (95\u2013160\u2003mg\u00b7dl<jats:sup>\u22121<\/jats:sup>). In 43 of 46 children, transfusion therapy was necessary. Despite of transfusion of fresh frozen plasma (cumulative total dose 22\u2003ml\u00b7kg<jats:sup>\u22121<\/jats:sup> [11\u201332\u2003ml\u00b7kg<jats:sup>\u22121<\/jats:sup>]) in 21 of 46 children, FXIII level remains low in all children till the end of surgery at levels of 39% (20\u201346%).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Coagulation factor XIII decreased early during major surgery owing to hemodilution. Overall intraoperative FXIII levels remain low despite of transfusion of fresh frozen plasma.<\/jats:p>","DOI":"10.1111\/j.1460-9592.2011.03709.x","type":"journal-article","created":{"date-parts":[[2011,9,20]],"date-time":"2011-09-20T20:27:27Z","timestamp":1316550447000},"page":"641-646","source":"Crossref","is-referenced-by-count":20,"title":["Perioperative course of FXIII in children undergoing major surgery"],"prefix":"10.1111","volume":"22","author":[{"given":"Thorsten","family":"Haas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Korte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelly","family":"Spielmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Mauch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caveh","family":"Madjdpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Schmugge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,9,20]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1999.01648.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-42584"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V70.1.165.165"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2009.02123.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000134800.46276.21"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-872853"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000017219.83330.FF"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1265746"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2257.2005.00681.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeq199"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2007.05186.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000280481.18570.27"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2005.00733.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000123012.24871.62"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aen270"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpa.2009.09.006"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181b5a263"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318194b21e"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0b013e3181684339"}],"container-title":["Pediatric Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1460-9592.2011.03709.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1460-9592.2011.03709.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T18:40:56Z","timestamp":1697308856000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1460-9592.2011.03709.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,20]]},"references-count":19,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1111\/j.1460-9592.2011.03709.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1460-9592.2011.03709.x","archive":["Portico"],"relation":{},"ISSN":["1155-5645","1460-9592"],"issn-type":[{"value":"1155-5645","type":"print"},{"value":"1460-9592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,20]]}}}