{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T04:16:31Z","timestamp":1697343391766},"reference-count":4,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,1,14]],"date-time":"2012-01-14T00:00:00Z","timestamp":1326499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p>The physiological application of OHMS LAW explains the basis of hypotensive anesthesia.<\/jats:p><jats:p>V\u2003=\u2003IR translates into:<\/jats:p><jats:p><jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Pressure\u2003=\u2003Flow\u2003\u00d7\u2003Resistance or<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Blood pressure\u2003=\u2003Cardiac Output\u2003\u00d7\u2003Peripheral Resistance.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><jats:p>If peripheral resistance is reduced by a vasodilator such as sodium nitroprusside (a short acting, vascular smooth muscle relaxant) or phenoxybenzamine (a long acting \u03b1 adrenoreceptor antagonist), blood pressure will fall and vasoconstriction and bleeding will be reduced. A less desirable alternative to lowering blood pressure could be to reduce cardiac output by suppressing myocardial contractility using a \u00df<jats:sub>1<\/jats:sub> adrenoceptor antagonist or an inhalational agent such as isoflurane.<\/jats:p>","DOI":"10.1111\/j.1460-9592.2012.03799.x","type":"journal-article","created":{"date-parts":[[2012,1,14]],"date-time":"2012-01-14T08:15:28Z","timestamp":1326528928000},"page":"720-722","source":"Crossref","is-referenced-by-count":3,"title":["Early experiences of vasodilators and hypotensive anesthesia in children"],"prefix":"10.1111","volume":"22","author":[{"given":"T.C.K.","family":"Brown","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,14]]},"reference":[{"key":"e_1_2_3_2_2","first-page":"480","article-title":"The actions and toxicity of sodium nitroprusside","volume":"35","author":"Johnson CC","year":"1929","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X8000800111"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00173076"},{"key":"e_1_2_3_5_2","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1177\/0310057X9202000315","article-title":"Anaesthesia for sacrococcygeal teratoma \u2013 a case report and review of 32 cases","volume":"20","author":"Robinson S","year":"1992","journal-title":"Anaesth Intensive Care"}],"container-title":["Pediatric Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1460-9592.2012.03799.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1460-9592.2012.03799.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T18:40:37Z","timestamp":1697308837000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1460-9592.2012.03799.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,14]]},"references-count":4,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1111\/j.1460-9592.2012.03799.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1460-9592.2012.03799.x","archive":["Portico"],"relation":{},"ISSN":["1155-5645","1460-9592"],"issn-type":[{"value":"1155-5645","type":"print"},{"value":"1460-9592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,14]]}}}