{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T09:50:35Z","timestamp":1786960235309,"version":"build-2736575974"},"reference-count":3,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2004,8,27]],"date-time":"2004-08-27T00:00:00Z","timestamp":1093564800000},"content-version":"vor","delay-in-days":57,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Seborrheic dermatitis is a common inflammatory skin disorder. Yeasts of the genus <jats:italic>Malassezia<\/jats:italic> have been implicated in the etiology of seborrheic dermatitis, although this connection remains controversial. Ciclopirox is a synthetic, hydroxypyridone\u2010derived, broad\u2010spectrum antifungal agent with anti\u2010inflammatory properties.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> A total of 499\u00a0US patients with seborrheic dermatitis of the scalp were randomized to apply either ciclopirox shampoo 1% or vehicle twice weekly for 4\u00a0weeks. The main efficacy parameters were based on 6\u2010point ordinal scales describing the disease's signs and symptoms (scaling, erythema and itching) and a 6\u2010point scale providing a global evaluation of the status of seborrheic dermatitis.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Ciclopirox was significantly better than vehicle in effectively treating seborrheic dermatitis. \u2018Effective treatment\u2019 (score of 0 or 1 for disease status, scaling and erythema) was achieved in 26.0% of ciclopirox\u2010treated patients compared with 12.9% of vehicle\u2010treated patients (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0001; OR: 2.383, 95% CI: 1.494\u20133.799). The majority of subjects experienced adverse events that were mild in intensity, with skin and appendage reactions the most commonly reported, at similar frequency in both groups.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Ciclopirox shampoo 1% is effective and safe in the treatment of seborrheic dermatitis of the scalp.<\/jats:p>","DOI":"10.1111\/j.1461-1244.2004.02409.x","type":"journal-article","created":{"date-parts":[[2004,8,27]],"date-time":"2004-08-27T09:30:56Z","timestamp":1093599056000},"page":"17-20","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Safety and efficacy of ciclopirox 1% shampoo for the treatment of seborrheic dermatitis of the scalp in the US population: Results of a double\u2010blind, vehicle\u2010controlled trial"],"prefix":"10.1111","volume":"43","author":[{"given":"Mark","family":"Lebwohl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Plott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,8,27]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0738-081X(91)90075-V"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1997.00309.x"},{"key":"e_1_2_6_4_2","first-page":"594","article-title":"Comparison of ciclopirox olamine 1% cream with ciclopirox 1%\u2010hydrocortisone acetate 1% cream in the treatment of inflamed superficial mycoses","volume":"10","author":"Lassus A","year":"1988","journal-title":"Clin Ther"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1461-1244.2004.02409.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1461-1244.2004.02409.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T04:50:21Z","timestamp":1696913421000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1461-1244.2004.02409.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7]]},"references-count":3,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["10.1111\/j.1461-1244.2004.02409.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1461-1244.2004.02409.x","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,7]]},"assertion":[{"value":"2004-08-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}