{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:55:15Z","timestamp":1791118515098,"version":"4.1.0"},"reference-count":77,"publisher":"Hindawi Limited","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1391,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1111\/j.1462-5822.2011.01713.x","type":"journal-article","created":{"date-parts":[[2011,10,11]],"date-time":"2011-10-11T08:56:37Z","timestamp":1318323397000},"page":"19-27","source":"Crossref","is-referenced-by-count":55,"title":["Legionella secreted effectors and innate immune responses"],"prefix":"10.1155","volume":"14","author":[{"given":"Zhao-Qing","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","published-online":{"date-parts":[[2011,11,10]]},"reference":[{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB1|cit1","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/j.1462-5822.2006.00785.x","article-title":"Anti-apoptotic signalling by the Dot\/Icm secretion system of L.\u2003pneumophila","volume":"9","author":"Abu-Zant","year":"2007","journal-title":"Cell Microbiol"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB2|cit2","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity","volume":"124","author":"Akira","year":"2006","journal-title":"Cell"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB3|cit3","doi-asserted-by":"crossref","first-page":"5429","DOI":"10.4049\/jimmunol.1000128","article-title":"Cutting edge: pulmonary Legionella pneumophila is controlled by plasmacytoid dendritic cells but not type I IFN","volume":"184","author":"Ang","year":"2010","journal-title":"J Immunol"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB5|cit4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1462-5822.2008.01234.x","article-title":"Multiple MyD88-dependent responses contribute to pulmonary clearance of Legionella pneumophila","volume":"11","author":"Archer","year":"2009","journal-title":"Cell Microbiol"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB4|cit5","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1128\/IAI.00243-10","article-title":"Cooperation between multiple microbial pattern recognition systems is important for host protection against the intracellular pathogen Legionella pneumophila","volume":"78","author":"Archer","year":"2010","journal-title":"Infect Immun"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB6|cit6","doi-asserted-by":"crossref","first-page":"5121","DOI":"10.1073\/pnas.0611030104","article-title":"Legionella pneumophila inhibits macrophage apoptosis by targeting pro-death members of the Bcl2 protein family","volume":"104","author":"Banga","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB7|cit7","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1111\/j.1462-5822.2009.01354.x","article-title":"Temporal resolution of two-tracked NF-kappaB activation by Legionella pneumophila","volume":"11","author":"Bartfeld","year":"2009","journal-title":"Cell Microbiol"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB8|cit8","doi-asserted-by":"crossref","first-page":"16953","DOI":"10.1073\/pnas.0601562103","article-title":"Legionella pneumophila glucosyltransferase inhibits host elongation factor 1A","volume":"103","author":"Belyi","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB9|cit9","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.1128\/JB.01798-07","article-title":"Lgt: a family of cytotoxic glucosyltransferases produced by Legionella pneumophila","volume":"190","author":"Belyi","year":"2008","journal-title":"J Bacteriol"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB10|cit10","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1038\/ni1006-1029","article-title":"On regulation of phagosome maturation and antigen presentation","volume":"7","author":"Blander","year":"2006","journal-title":"Nat Immunol"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB11|cit11","doi-asserted-by":"crossref","first-page":"4846","DOI":"10.1074\/jbc.M807505200","article-title":"Rab1 guanine nucleotide exchange factor SidM is a major phosphatidylinositol 4-phosphate-binding effector protein of Legionella pneumophila","volume":"284","author":"Brombacher","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB12|cit12","doi-asserted-by":"crossref","first-page":"e1000538","DOI":"10.1371\/journal.ppat.1000538","article-title":"Salmonella Typhimurium type III secretion effectors stimulate innate immune responses in cultured epithelial cells","volume":"5","author":"Bruno","year":"2009","journal-title":"PLoS Pathog"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB13|cit13","doi-asserted-by":"crossref","first-page":"e1000508","DOI":"10.1371\/journal.ppat.1000508","article-title":"Genome-scale identification of Legionella pneumophila effectors using a machine learning approach","volume":"5","author":"Burstein","year":"2009","journal-title":"PLoS Pathog"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB14|cit14","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1038\/ng1447","article-title":"Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity","volume":"36","author":"Cazalet","year":"2004","journal-title":"Nat Genet"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB15|cit15","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1126\/science.1099776","article-title":"The genomic sequence of the accidental pathogen Legionella pneumophila","volume":"305","author":"Chien","year":"2004","journal-title":"Science"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB16|cit16","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.cell.2009.06.015","article-title":"RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway","volume":"138","author":"Chiu","year":"2009","journal-title":"Cell"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB18|cit17","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.1371\/journal.ppat.0020034","article-title":"RNA interference analysis of Legionella in Drosophila cells: exploitation of early secretory apparatus dynamics","volume":"2","author":"Dorer","year":"2006","journal-title":"PLoS Pathog"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB19|cit18","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.mib.2008.12.004","article-title":"Legionella pneumophila Dot\/Icm translocated substrates: a sum of parts","volume":"12","author":"Ensminger","year":"2009","journal-title":"Curr Opin Microbiol"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB20|cit19","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/j.1462-5822.2005.00633.x","article-title":"Dictyostelium transcriptional host cell response upon infection with Legionella","volume":"8","author":"Farbrother","year":"2006","journal-title":"Cell Microbiol"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB17|cit20","doi-asserted-by":"crossref","first-page":"e1000117","DOI":"10.1371\/journal.ppat.1000117","article-title":"Legionella eukaryotic-like type IV substrates interfere with organelle trafficking","volume":"4","author":"de Felipe","year":"2008","journal-title":"PLoS Pathog"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB21|cit21","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1128\/CMR.15.3.506-526.2002","article-title":"Legionella and Legionnaires' disease: 25 years of investigation","volume":"15","author":"Fields","year":"2002","journal-title":"Clin Microbiol Rev"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB22|cit22","doi-asserted-by":"crossref","first-page":"e1001289","DOI":"10.1371\/journal.ppat.1001289","article-title":"Secreted bacterial effectors that inhibit host protein synthesis are critical for induction of the innate immune response to virulent Legionella pneumophila","volume":"7","author":"Fontana","year":"2011","journal-title":"PLoS Pathog"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB23|cit23","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nrm2272","article-title":"Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology","volume":"8","author":"Forgac","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB24|cit24","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1083\/jcb.200106049","article-title":"Role of phosphatidylinositol 3-kinase and Rab5 effectors in phagosomal biogenesis and mycobacterial phagosome maturation arrest","volume":"154","author":"Fratti","year":"2001","journal-title":"J Cell Biol"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB25|cit25","doi-asserted-by":"crossref","first-page":"13725","DOI":"10.1073\/pnas.0907200106","article-title":"A Legionella type IV effector activates the NF-kappaB pathway by phosphorylating the IkappaB family of inhibitors","volume":"106","author":"Ge","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB26|cit26","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S0952-7915(01)00309-0","article-title":"Phagocytosis and innate immunity","volume":"14","author":"Greenberg","year":"2002","journal-title":"Curr Opin Immunol"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB27|cit27","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3389\/fmicb.2011.00064","article-title":"Control of host cell phosphorylation by Legionella pneumophila","volume":"2","author":"Haenssler","year":"2011","journal-title":"Front Microbiol"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB28|cit28","doi-asserted-by":"crossref","first-page":"6758","DOI":"10.1038\/sj.onc.1209943","article-title":"NF-kappaB and the immune response","volume":"25","author":"Hayden","year":"2006","journal-title":"Oncogene"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB29|cit29","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1462-5822.2008.01249.x","article-title":"Large-scale identification of Legionella pneumophila Dot\/Icm substrates that modulate host cell vesicle trafficking pathways","volume":"11","author":"Heidtman","year":"2009","journal-title":"Cell Microbiol"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB30|cit30","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1128\/IAI.00805-10","article-title":"Protein kinase LegK2 is a type IV secretion system effector involved in endoplasmic reticulum recruitment and intracellular replication of Legionella pneumophila","volume":"79","author":"Hervet","year":"2011","journal-title":"Infect Immun"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB31|cit31","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.cyto.2009.08.002","article-title":"Regulation of JNK and p38 MAPK in the immune system: signal integration, propagation and termination","volume":"48","author":"Huang","year":"2009","journal-title":"Cytokine"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB32|cit32","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1462-5822.2010.01531.x","article-title":"The E Block motif is associated with Legionella pneumophila translocated substrates","volume":"13","author":"Huang","year":"2010","journal-title":"Cell Microbiol"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB33|cit33","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/nature06336","article-title":"Legionella pneumophila proteins that regulate Rab1 membrane cycling","volume":"450","author":"Ingmundson","year":"2007","journal-title":"Nature"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB34|cit34","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrmicro1967","article-title":"The Legionella pneumophila replication vacuole: making a cosy niche inside host cells","volume":"7","author":"Isberg","year":"2009","journal-title":"Nat Rev Microbiol"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB35|cit35","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nrd2289","article-title":"Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses","volume":"6","author":"Jeffrey","year":"2007","journal-title":"Nat Rev Drug Discov"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB36|cit36","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1038\/ncb883","article-title":"Legionella phagosomes intercept vesicular traffic from endoplasmic reticulum exit sites","volume":"4","author":"Kagan","year":"2002","journal-title":"Nat Cell Biol"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB37|cit37","doi-asserted-by":"crossref","first-page":"e1001216","DOI":"10.1371\/journal.ppat.1001216","article-title":"Legionella metaeffector exploits host proteasome to temporally regulate cognate effector","volume":"6","author":"Kubori","year":"2010","journal-title":"PLoS Pathog"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB38|cit38","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1084\/jem.20060792","article-title":"Essential role of IPS-1 in innate immune responses against RNA viruses","volume":"203","author":"Kumar","year":"2006","journal-title":"J Exp Med"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB39|cit39","doi-asserted-by":"crossref","first-page":"18745","DOI":"10.1073\/pnas.0609012103","article-title":"A Legionella pneumophila-translocated substrate that is required for growth within macrophages and protection from host cell death","volume":"103","author":"Laguna","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB40|cit40","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.chom.2009.08.005","article-title":"The amoebal MAP kinase response to Legionella pneumophila is regulated by DupA","volume":"6","author":"Li","year":"2009","journal-title":"Cell Host Microbe"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB41|cit41","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1111\/j.1462-5822.2011.01646.x","article-title":"Dissection of a type I interferon pathway in controlling bacterial intracellular infection in mice","volume":"13","author":"Lippmann","year":"2011","journal-title":"Cell Microbiol"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB43|cit42","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1128\/IAI.01278-06","article-title":"The Legionella pneumophila effector SidJ is required for efficient recruitment of endoplasmic reticulum proteins to the bacterial phagosome","volume":"75","author":"Liu","year":"2007","journal-title":"Infect Immun"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB42|cit43","doi-asserted-by":"crossref","first-page":"4108","DOI":"10.3748\/wjg.v11.i26.4108","article-title":"Correlation of Chlamydia pneumoniae infection with primary biliary cirrhosis","volume":"11","author":"Liu","year":"2005","journal-title":"World J Gastroenterol"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB45|cit44","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1084\/jem.20060766","article-title":"NF-kappaB translocation prevents host cell death after low-dose challenge by Legionella pneumophila","volume":"203","author":"Losick","year":"2006","journal-title":"J Exp Med"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB44|cit45","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1111\/j.1462-5822.2010.01452.x","article-title":"LnaB: a Legionella pneumophila activator of NF-kappaB","volume":"12","author":"Losick","year":"2010","journal-title":"Cell Microbiol"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB46|cit46","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3389\/fmicb.2011.00031","article-title":"Targeting one of its own: expanding roles of substrates of the Legionella pneumophila Dot\/Icm type IV secretion system","volume":"2","author":"Luo","year":"2011","journal-title":"Front Microbiol"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB47|cit47","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1073\/pnas.0304916101","article-title":"Multiple substrates of the Legionella pneumophila Dot\/Icm system identified by interbacterial protein transfer","volume":"101","author":"Luo","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB48|cit48","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.devcel.2006.05.013","article-title":"Targeting of host Rab GTPase function by the intravacuolar pathogen Legionella pneumophila","volume":"11","author":"Machner","year":"2006","journal-title":"Dev Cell"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB49|cit49","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1126\/science.1149121","article-title":"A bifunctional bacterial protein links GDI displacement to Rab1 activation","volume":"318","author":"Machner","year":"2007","journal-title":"Science"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB50|cit50","doi-asserted-by":"crossref","first-page":"e1000665","DOI":"10.1371\/journal.ppat.1000665","article-title":"Identification of host cytosolic sensors and bacterial factors regulating the type I interferon response to Legionella pneumophila","volume":"5","author":"Monroe","year":"2009","journal-title":"PLoS Pathog"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB51|cit51","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nature10335","article-title":"Modulation of Rab GTPase function by a protein phosphocholine transferase","volume":"477","author":"Mukherjee","year":"2011","journal-title":"Nature"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB52|cit52","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1126\/science.1192276","article-title":"The Legionella effector protein DrrA AMPylates the membrane traffic regulator Rab1b","volume":"329","author":"Muller","year":"2010","journal-title":"Science"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB53|cit53","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/ncb1463","article-title":"The Legionella pneumophila effector protein DrrA is a Rab1 guanine nucleotide-exchange factor","volume":"8","author":"Murata","year":"2006","journal-title":"Nat Cell Biol"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB54|cit54","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1126\/science.1067025","article-title":"A bacterial guanine nucleotide exchange factor activates ARF on Legionella phagosomes","volume":"295","author":"Nagai","year":"2002","journal-title":"Science"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB55|cit55","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1111\/j.1462-5822.2004.00450.x","article-title":"Immunity to vacuolar pathogens: what can we learn from Legionella?","volume":"6","author":"Neild","year":"2004","journal-title":"Cell Microbiol"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB56|cit56","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1126\/science.1207193","article-title":"De-AMPylation of the small GTPase Rab1 by the pathogen Legionella pneumophila","volume":"333","author":"Neunuebel","year":"2011","journal-title":"Science"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB57|cit57","doi-asserted-by":"crossref","first-page":"36173","DOI":"10.1074\/jbc.M604638200","article-title":"Legionella pneumophila induces IFNbeta in lung epithelial cells via IPS-1 and IRF3, which also control bacterial replication","volume":"281","author":"Opitz","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB58|cit58","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1111\/j.1462-5822.2005.00666.x","article-title":"Attachment and fusion of endoplasmic reticulum with vacuoles containing Legionella pneumophila","volume":"8","author":"Robinson","year":"2006","journal-title":"Cell Microbiol"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB59|cit59","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.ceb.2006.06.002","article-title":"Molecular mechanisms of late endosome morphology, identity and sorting","volume":"18","author":"Russell","year":"2006","journal-title":"Curr Opin Cell Biol"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB60|cit60","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1111\/j.1462-5822.2009.01301.x","article-title":"Targeting eEF1A by a Legionella pneumophila effector leads to inhibition of protein synthesis and induction of host stress response","volume":"11","author":"Shen","year":"2009","journal-title":"Cell Microbiol"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB62|cit61","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1111\/j.1462-5822.2008.01145.x","article-title":"Host cell processes that influence the intracellular survival of Legionella pneumophila","volume":"10","author":"Shin","year":"2008","journal-title":"Cell Microbiol"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB61|cit62","doi-asserted-by":"crossref","first-page":"e1000220","DOI":"10.1371\/journal.ppat.1000220","article-title":"Type IV secretion-dependent activation of host MAP kinases induces an increased proinflammatory cytokine response to Legionella pneumophila","volume":"4","author":"Shin","year":"2008","journal-title":"PLoS Pathog"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB63|cit63","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/nrm2728","article-title":"Rab GTPases as coordinators of vesicle traffic","volume":"10","author":"Stenmark","year":"2009","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB64|cit64","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.immuni.2005.12.003","article-title":"Recognition of cytosolic DNA activates an IRF3-dependent innate immune response","volume":"24","author":"Stetson","year":"2006","journal-title":"Immunity"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB65|cit65","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1084\/jem.192.9.1261","article-title":"Legionella pneumophila replication vacuoles mature into acidic, endocytic organelles","volume":"192","author":"Sturgill-Koszycki","year":"2000","journal-title":"J Exp Med"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB66|cit66","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1146\/annurev.micro.54.1.567","article-title":"Legionella pneumophila pathogesesis: a fateful journey from amoebae to macrophages","volume":"54","author":"Swanson","year":"2000","journal-title":"Annu Rev Microbiol"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB67|cit67","doi-asserted-by":"crossref","first-page":"3609","DOI":"10.1128\/IAI.63.9.3609-3620.1995","article-title":"Association of Legionella pneumophila with the macrophage endoplasmic reticulum","volume":"63","author":"Swanson","year":"1995","journal-title":"Infect Immun"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB68|cit68","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/nature10307","article-title":"Legionella pneumophila SidD is a deAMPylase that modifies Rab1","volume":"475","author":"Tan","year":"2011","journal-title":"Nature"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB69|cit69","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1242\/jcs.114.24.4637","article-title":"How the parasitic bacterium Legionella pneumophila modifies its phagosome and transforms it into rough ER: implications for conversion of plasma membrane to the ER membrane","volume":"114","author":"Tilney","year":"2001","journal-title":"J Cell Sci"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB70|cit70","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1126\/science.1184004","article-title":"How the noninflammasome NLRs function in the innate immune system","volume":"327","author":"Ting","year":"2010","journal-title":"Science"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB71|cit71","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1600-0854.2008.00851.x","article-title":"Proteome analysis of Legionella vacuoles purified by magnetic immunoseparation reveals secretory and endosomal GTPases","volume":"10","author":"Urwyler","year":"2009","journal-title":"Traffic"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB72|cit72","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s10875-010-9389-2","article-title":"Immunology taught by bacteria","volume":"30","author":"Vance","year":"2010","journal-title":"J Clin Immunol"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB73|cit73","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.chom.2009.06.007","article-title":"Patterns of pathogenesis: discrimination of pathogenic and nonpathogenic microbes by the innate immune system","volume":"6","author":"Vance","year":"2009","journal-title":"Cell Host Microbe"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB74|cit74","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1126\/science.279.5352.873","article-title":"Conjugative transfer by the virulence system of Legionella pneumophila","volume":"279","author":"Vogel","year":"1998","journal-title":"Science"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB75|cit75","doi-asserted-by":"crossref","first-page":"e46","DOI":"10.1371\/journal.ppat.0020046","article-title":"Legionella pneumophila exploits PI(4)P to anchor secreted effector proteins to the replicative vacuole","volume":"2","author":"Weber","year":"2006","journal-title":"PLoS Pathog"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB76|cit76","doi-asserted-by":"crossref","first-page":"e1000822","DOI":"10.1371\/journal.ppat.1000822","article-title":"Inhibition of host vacuolar H+-ATPase activity by a Legionella pneumophila effector","volume":"6","author":"Xu","year":"2010","journal-title":"PLoS Pathog"},{"key":"10.1111\/j.1462-5822.2011.01713.x-BIB77|cit77","doi-asserted-by":"crossref","first-page":"e17638","DOI":"10.1371\/journal.pone.0017638","article-title":"Comprehensive identification of protein substrates of the Dot\/Icm type IV transporter of Legionella pneumophila","volume":"6","author":"Zhu","year":"2011","journal-title":"PLoS ONE"}],"container-title":["Cellular Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1462-5822.2011.01713.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/j.1462-5822.2011.01713.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T06:02:53Z","timestamp":1643349773000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1462-5822.2011.01713.x"}},"subtitle":["Interactions between Dot\/Icm substrates and host immune systems"],"short-title":[],"issued":{"date-parts":[[2011,11,10]]},"references-count":77,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1462-5822.2011.01713.x","relation":{},"ISSN":["1462-5814"],"issn-type":[{"value":"1462-5814","type":"print"}],"subject":[],"published":{"date-parts":[[2011,11,10]]}}}