{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:38:04Z","timestamp":1790163484064,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,5,26]],"date-time":"2004-05-26T00:00:00Z","timestamp":1085529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:p>\n                    <jats:bold>Aim:\u2002<\/jats:bold>\n                    Resistin, a novel hormone, is expressed in mouse, rat and human adipose tissue. Its resistance to insulin is controversial. We hypothesized that resistin has the similar roles like those of tumour necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), a putative mediator of insulin resistance, and they are in common involved in regulating lipid metabolism\n                    <jats:italic>in vivo<\/jats:italic>\n                    .\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:\u2002<\/jats:bold>\n                    We demonstrated TNF\u2010\u03b1 and resistin expression in different growth\u2010stage adipose tissue of genetically lean and obese pigs using semiquantitative reverse transcriptase\u2010polymerase chain reaction and Western blotting analysis. Moreover, we analysed the variations of resistin and some parameters associated with lipolysis pathway after body\u2010weight reduction in feeding\u2010restricted obese pigs. In addition, we localized resistin expression in the cell types from pig adipose tissue.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:\u2002<\/jats:bold>\n                    Overall, the expression of TNF\u2010\u03b1 and resistin in obese pigs was statistically higher than their lean counterparts, although this difference in resistin mRNA expression tailed off with age. In individual pigs, their levels increased progressively with age and degree of obesity. After feeding restriction, resistin expression was gradually decreased. Simultaneously, feeding restriction also resulted in a significant decrease of serum triglyceride and plasma cAMP, free fatty acids and insulin as well as fat adenyl cyclase and cAMP. In addition, in isolated pig adipocytes, our data showed that resistin was localized not only to adipocytes but also to other unidentified stromal vascular cells.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:\u2002<\/jats:bold>\n                    TNF\u2010\u03b1 and resistin are increased in obesity. Weight loss results in the decrease of resistin and lipolysis\u2010associated parameters, suggesting the possible association between resistin and lipolysis pathway. Cell localization of resistin expression implies the possibility of other biological actions of resistin.\n                  <\/jats:p>","DOI":"10.1111\/j.1462-8902.2004.0346.x","type":"journal-article","created":{"date-parts":[[2004,5,26]],"date-time":"2004-05-26T07:44:17Z","timestamp":1085557457000},"page":"271-279","source":"Crossref","is-referenced-by-count":20,"title":["Increased expression of resistin and tumour necrosis factor\u2010\u03b1 in pig adipose tissue as well as effect of feeding treatment on resistin and cAMP pathway"],"prefix":"10.1111","volume":"6","author":[{"given":"X. D.","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z. 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