{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,15]],"date-time":"2026-11-15T03:31:01Z","timestamp":1794713461395,"version":"4.9.1"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,12,14]],"date-time":"2004-12-14T00:00:00Z","timestamp":1102982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2003<\/jats:bold> Patients with inoperable advanced rectal carcinoma require palliation for local symptoms. Endoscopic Nd\u2010Yag laser ablation is a valid palliative treatment option in patients with advanced rectal carcinoma who are poor operative risks due to coexistent multiple comorbidities.<\/jats:p><jats:p><jats:bold>Methods\u2003<\/jats:bold> All patients who cannot undergo radical surgery due to various factors such as tumour size, poor risk patients, distant metastasis and refusal to undergo surgery were offered palliation with endoscopic Nd\u2010YAG laser ablation. Indications included troublesome bleeding, local recurrence, mucous discharge and impending obstruction. Patients were admitted on the day of treatment, phosphate enema given for bowel preparation and endoscopic ablation done through a flexible sigmoidoscope under intravenous sedation with midazolam. All patients were discharged the next day after overnight observation. Patients were reviewed every 3\u2003months and laser ablation repeated if deemed necessary.<\/jats:p><jats:p><jats:bold>Results\u2003<\/jats:bold> Eleven patients (7 males, 4 females; mean age 83.6 years, range 77\u201390 years) underwent endoscopic laser ablation in a District General Hospital \u2013 8 for rectal carcinoma, 2 for rectosigmoid tumour and 1 for recurrent tubulovillous adenoma. The number of treatment episodes varied from 1 to 12 with symptom free interval from 2 to 18\u2003months between treatment episodes. There were 3 failures, one patient required defunctioning colostomy, one patient was referred for radiotherapy due to persistent symptoms and in one patient laser treatment had to be abandoned due to local extent. There were no immediate post\u2010treatment complications, but one patient developed incontinence after 5 episodes which might be attributable to tumour infiltration.<\/jats:p><jats:p><jats:bold>Discussion\u2003<\/jats:bold> Endoscopic laser ablation is a practical and feasible alternative to other palliative treatment modalities in the management of this unfortunate category of patients due to low morbidity and mortality, short hospitalization and low complication rates.<\/jats:p>","DOI":"10.1111\/j.1463-1318.2004.00733.x","type":"journal-article","created":{"date-parts":[[2004,12,14]],"date-time":"2004-12-14T09:31:36Z","timestamp":1103016696000},"page":"58-60","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Endoscopic laser ablation of advanced rectal carcinoma \u2013 a DGH experience"],"prefix":"10.1111","volume":"7","author":[{"given":"V. S. 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