{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:49:54Z","timestamp":1778629794691,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,2,18]],"date-time":"2005-02-18T00:00:00Z","timestamp":1108684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2003<\/jats:bold> Suprasphincteric fistulae remain the most difficult to cure.<\/jats:p><jats:p><jats:bold>Objectives\u2003<\/jats:bold> The purpose of this study was to evaluate the healing rate of suprasphincteric anal fistula treated by ano\u2010cutaneous advancement flap repair, and the impact of this procedure on continence and quality of life.<\/jats:p><jats:p><jats:bold>Method\u2003<\/jats:bold> Sixteen patients with complex, recurrent or chronic suprasphincteric fistulae associated with significant tissue damage (necrotizing fasciitis, keyhole deformity and anal stenosis) or who had failed previous surgical procedures were treated by ano\u2010cutaneous flap closure. They were assessed pre and postoperatively by the treating surgeon for wound healing and fistula recurrence and later followed up by phone interview using the St Mark's Hospital incontinence score and the Perianal Disease Activity Index (PDAI) as indicators of treatment outcome.<\/jats:p><jats:p><jats:bold>Results\u2003<\/jats:bold> Fifteen patients had successful healing of their fistula with the cutaneous flap, with recurrence in only one. The most common short\u2010term complications were minor graft site wound separation, which healed in all cases without intervention, and wound pain, which settled over time and was not associated with recurrence. Continence improved for almost 70% of the patients, with a significant reduction in St Mark's incontinence scores (t\u2003=\u20032.62, 15 d.f., <jats:italic>P<\/jats:italic>\u2003=\u20030.02). PDAI also decreased significantly (t\u2003=\u20037.55, 15 d.f., <jats:italic>P<\/jats:italic>\u2003&lt; 0.001), demonstrating improvement in quality of life for most patients.<\/jats:p><jats:p><jats:bold>Conclusion\u2003<\/jats:bold> Ano\u2010cutaneous flap can achieve healing of complex and recurrent suprasphincteric anal fistula in patients who had previously failed at other forms of treatment thus improving their quality of life and continence.<\/jats:p>","DOI":"10.1111\/j.1463-1318.2004.00745.x","type":"journal-article","created":{"date-parts":[[2005,2,18]],"date-time":"2005-02-18T09:36:53Z","timestamp":1108719413000},"page":"187-192","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Ano\u2010cutaneous flap repair for complex and recurrent supra \u2013 sphincteric anal fistula"],"prefix":"10.1111","volume":"7","author":[{"given":"T.","family":"Hossack","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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