{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T15:40:22Z","timestamp":1773157222257,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,9,12]],"date-time":"2006-09-12T00:00:00Z","timestamp":1158019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> To assess the 3\u2010year outcomes of a nurse\u2010led, one\u2010stop, 2\u2010week rule (TWR) clinic for suspected colorectal cancer (CRC) in a large teaching hospital.<\/jats:p><jats:p><jats:bold>Method\u2002<\/jats:bold> Data were collected prospectively from January 2002 to December 2004. In total, 2748 patients were seen over the 3\u2010year period. The ratio of male:female subjects was 1190:1558 (43%:57%). Median age at presentation was 66\u2003years (range 17\u201396).<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> A total of 1363 (49.6%) nonconforming referrals were made; 1300 patients (47.3%) underwent flexible sigmoidoscopy during their initial assessment in clinic; 1439 patients (52.4%) underwent a barium enema during the course of their investigation; 2503 patients (91.1%) were seen within 14 working days. The median overall wait for the initial clinic appointment was 10\u2003days. The annual number of patients seen was similar over the 3\u2010year period. A total of 174 cancers (6.3%) were identified which accounted for 36.4% of all CRCs diagnosed during the study period. Nineteen cancers presented in the nonconforming group (1.6% of all non\u2010conforming patients). Rectal tumours accounted for 59.8% (<jats:italic>n<\/jats:italic>\u2003=\u2003104) of all cancers diagnosed while right\u2010sided tumours accounted for only 10.9% (<jats:italic>n<\/jats:italic>\u2003=\u200319). Advanced tumours accounted for 73.0% (<jats:italic>n<\/jats:italic>\u2003=\u2003127) of the total; 133 (76.4%) cancer patients underwent some form of surgical intervention.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> A specialist nurse\u2010led, one\u2010stop TWR clinic for suspected colorectal cancer is sustainable and can be run successfully with over 90% of referrals seen within the targeted time period. The proportion of non\u2010conforming referrals was high and a large number of advanced and unstaged tumours was observed. Low numbers of proximal tumours were detected.<\/jats:p>","DOI":"10.1111\/j.1463-1318.2006.01048.x","type":"journal-article","created":{"date-parts":[[2006,9,12]],"date-time":"2006-09-12T14:28:35Z","timestamp":1158071315000},"page":"340-343","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Outcomes in 2748 patients referred to a colorectal two\u2010week rule clinic"],"prefix":"10.1111","volume":"9","author":[{"given":"R. A.","family":"Smith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Oshin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"McCallum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Randles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Delamere","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. S.","family":"Rooney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. S.","family":"Carter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9,12]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.47.4.533"},{"key":"e_1_2_5_3_2","volume-title":"NHS Cancer Plan\/The New NHS","author":"Department of Health","year":"2000"},{"key":"e_1_2_5_4_2","volume-title":"Improving Outcomes in Colorectal Cancer","author":"Department of Health","year":"2000"},{"key":"e_1_2_5_5_2","volume-title":"Referral Guidelines for Bowel Cancer","author":"Department of Health","year":"2000"},{"key":"e_1_2_5_6_2","first-page":"59","article-title":"New guidelines for urgent referral of patients with cancer a waste of energy","volume":"320","author":"Sikora K","year":"2000","journal-title":"BMJ"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.12968\/hosp.2000.61.7.1372"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/pmj.78.926.748"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.322.7290.830"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38153.491887.7C"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004640090120"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-1318.2003.00406.x"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1463-1318.2006.01048.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1463-1318.2006.01048.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T08:47:29Z","timestamp":1743929249000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1463-1318.2006.01048.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,12]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["10.1111\/j.1463-1318.2006.01048.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1463-1318.2006.01048.x","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9,12]]},"assertion":[{"value":"2006-09-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}