{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T23:32:04Z","timestamp":1778196724810,"version":"3.51.4"},"reference-count":54,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,11,13]],"date-time":"2006-11-13T00:00:00Z","timestamp":1163376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective\u2002<\/jats:bold>\n                    Colonic propagating sequences are important for normal colonic transit and defecation. The frequency of these motor patterns is reduced in slow\u2010transit constipation. Sacral nerve stimulation (SNS) is a useful treatment for faedcal and urinary incontinence. A high proportion of these patients have also reported altered bowel function. The effects of SNS on colonic propagating sequences in constipation are unknown. Our aims were to evaluate the effect of SNS on colonic pressure patterns and evaluate its therapeutic potential in severe constipation.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Method\u2002<\/jats:bold>\n                    In eight patients with scintigraphically confirmed slow\u2010transit constipation, a manometry catheter (16 recording sites at 7.5\u2003cm intervals) was positioned colonoscopically and the tip fixed in the caecum. Temporary electrodes (Medtronic) were implanted in the S2 and S3 sacral nerve foramina under general anaesthesia. In the fasted state, 14\u2003Hz stimulation was administered and four sets of parameters (pulse width 300 or 400\u2003\n                    <jats:italic>\u03bc<\/jats:italic>\n                    s; S2 and S3) were tested in four 2\u2010h epochs, in random order, over 2\u2003days. Patients were then discharged home with the sacral wires\n                    <jats:italic>in situ<\/jats:italic>\n                    and a 3\u2010week trial stimulation commenced during which patients completed a daily stool diary.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results\u2002<\/jats:bold>\n                    When compared with basal activity, electrical stimulation to S3 significantly increased pan\u2010colonic antegrade propagating sequence (PS) frequency (5.4\u2003\u00b1\u20034.2\n                    <jats:italic>vs<\/jats:italic>\n                    11.3\u2003\u00b1\u20036.6\u2003PS\/h;\n                    <jats:italic>P<\/jats:italic>\n                    \u2003=\u20030.01). Stimulation at S2 significantly increased retrograde PSs (basal 2.6\u2003\u00b1\u20031.8\n                    <jats:italic>vs<\/jats:italic>\n                    SNS 5.6\u2003\u00b1\u20034.8\u2003PS\/h;\n                    <jats:italic>P<\/jats:italic>\n                    \u2003=\u20030.03). During the subsequent three\u2010week trial (continuous stimulation), six of eight reported increased bowel frequency with a reduction in laxative usage.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion\u2002<\/jats:bold>\n                    These data demonstrate that SNS induces pan\u2010colonic propagating pressure waves and therefore shows promise as a potential therapy for severe refractory constipation.\n                  <\/jats:p>","DOI":"10.1111\/j.1463-1318.2006.01096.x","type":"journal-article","created":{"date-parts":[[2006,11,13]],"date-time":"2006-11-13T12:39:10Z","timestamp":1163421550000},"page":"123-132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":153,"title":["Sacral nerve stimulation induces pan\u2010colonic propagating pressure waves and increases defecation frequency in patients with slow\u2010transit constipation"],"prefix":"10.1111","volume":"9","author":[{"given":"P. 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