{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T05:05:24Z","timestamp":1783573524730,"version":"3.55.0"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,11,28]],"date-time":"2006-11-28T00:00:00Z","timestamp":1164672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> Some haemorrhoids are associated with high resting anal canal pressures. The aim of this study was to assess if Rectogesic\u00ae, a topical glyceryl trinitrate 0.2% ointment was effective in relieving symptoms of early grade haemorrhoids associated with high resting anal canal pressures.<\/jats:p><jats:p><jats:bold>Method\u2002<\/jats:bold> This was a prospective, two\u2010centre, open label study of 58 patients with persistent haemorrhoidal symptoms. Patients with first or second degree haemorrhoids and a maximum resting anal canal pressure &gt;70\u2003mmHg were included. Rectogesic\u00ae was applied three times a day for 14\u2003days. Anorectal manometry was performed 30\u2003min after the first application of Rectogesic\u00ae. A 28\u2010day diary was completed during 14\u2003days of therapy and for 14\u2003days after cessation of treatment. This recorded the incidence of rectal bleeding, and visual analogue scales for anal pain, throbbing, pruritis, irritation and difficulty in bowel movement.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Maximum resting anal canal pressures were reduced after application of Rectogesic\u00ae (115.0\u2003\u00b1 40.4\u2003mmHg <jats:italic>vs<\/jats:italic> 94.7\u2003\u00b1\u200334.1\u2003mmHg, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). In the study period and at 14\u2003days after cessation of Rectogesic\u00ae, there was significant reduction in rectal bleeding (<jats:italic>P<\/jats:italic>\u2003=\u20030.0002), and significant improvement of anal pain (<jats:italic>P<\/jats:italic>\u2003=\u20030.0024), throbbing (<jats:italic>P<\/jats:italic>\u2003=\u20030.0355), pruritis (<jats:italic>P<\/jats:italic>\u2003= 0.0043), irritation (<jats:italic>P<\/jats:italic>\u2003=\u20030.0000) and difficulty in bowel movement (<jats:italic>P<\/jats:italic>\u2003=\u20030.001). The main adverse event was headache in 43.1% of patients.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Rectogesic\u00ae is a safe and feasible treatment for patients with early grade haemorrhoids associated with high resting anal canal pressures.<\/jats:p>","DOI":"10.1111\/j.1463-1318.2006.01134.x","type":"journal-article","created":{"date-parts":[[2006,11,28]],"date-time":"2006-11-28T13:40:37Z","timestamp":1164721237000},"page":"457-463","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Rectogesic\u00ae (glyceryl trinitrate 0.2%) ointment relieves symptoms of haemorrhoids associated with high resting anal canal pressures"],"prefix":"10.1111","volume":"9","author":[{"given":"J. J.","family":"Tjandra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. J. 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