{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T22:31:33Z","timestamp":1788820293695,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,1,15]],"date-time":"2007-01-15T00:00:00Z","timestamp":1168819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> To assess the association between self\u2010reported symptoms and a diagnosis of colorectal cancer (CRC) in symptomatic outpatients without CRC risk factors, defined by a Danish expert group.<\/jats:p><jats:p><jats:bold>Method\u2002<\/jats:bold> A cross\u2010sectional study of patients aged 40\u2003years and older referred by general practitioners to two Danish surgical outpatient clinics for symptoms consistent with CRC during a 16\u2010month period. CRC was diagnosed at endoscopy and through follow up. Before their first appointment, participants completed a questionnaire about symptoms.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The study included 2172 patients. Of these, 122 were diagnosed with CRC (5.6%). Median age was 61\u2003years (range: 40\u201397) and 44.0% were men. All symptoms had high (93.4\u201396.8%) negative predictive values for CRC. The highest positive predictive values (PPV) were found for dark rectal bleeding (PPV: 20.6%) and CRC was diagnosed in a first\u2010degree relative over the age of 50\u2003years (PPV: 11.2%). At multiple logistic regression analysis dark rectal blood was the most important predictor of CRC (OR: 7.4). Other predictors were age 60\u2003years or older (OR: 3.0), change in frequency of bowel movements (OR: 2.5), CRC diagnosed in a first\u2010degree relative over the age of 50\u2003years (OR: 2.6), male gender (OR: 2.2) and mono\u2010symptomatic fresh rectal blood (OR: 1.7).<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> No self\u2010reported symptoms presented by outpatients without CRC risk factors can be used accurately to identify patients with CRC with certainty. For clinical purposes self\u2010reported symptoms seems thus not to be a useful accurate tool to distinguish between symptomatic outpatients with and without CRC.<\/jats:p>","DOI":"10.1111\/j.1463-1318.2006.01170.x","type":"journal-article","created":{"date-parts":[[2007,1,15]],"date-time":"2007-01-15T09:20:15Z","timestamp":1168852815000},"page":"443-451","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Diagnostic value of self\u2010reported symptoms in Danish outpatients referred with symptoms consistent with colorectal cancer"],"prefix":"10.1111","volume":"9","author":[{"given":"N. C.","family":"Bjerregaard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"T\u00f8ttrup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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