{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:17:04Z","timestamp":1782519424039,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,1,4]],"date-time":"2007-01-04T00:00:00Z","timestamp":1167868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> Anal fissure is a common painful condition affecting the anal canal and causes considerable morbidity and reduction in quality of life. Surgical treatment has been associated with a degree of incontinence in up to 30% of patients. This study discussed the results of clove oil 1% cream in healing of chronic anal fissure.<\/jats:p><jats:p><jats:bold>Method\u2002<\/jats:bold> A single\u2010blind randomized comparative trial was setup to compare traditional treatment with stool softeners and lignocaine cream 5% against clove oil 1% cream for 6\u2003weeks.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> 55 patients were included in this study, 30 patients in clove oil group and 25 patients in control group. Healing had occurred in 60% of patients in clove oil group and in 12% of patients in the control group after 3\u2010month follow up (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). Patients in clove oil group showed significant reduction in resting anal pressure and almost all other anorectal manometric pressures compared with patients in control group.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Topical application of clove oil cream demonstrated a significant beneficial effect when applied to patients suffering from chronic anal fissure.<\/jats:p>","DOI":"10.1111\/j.1463-1318.2006.01185.x","type":"journal-article","created":{"date-parts":[[2007,1,4]],"date-time":"2007-01-04T20:24:06Z","timestamp":1167942246000},"page":"549-552","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Clove oil cream: a new effective treatment for chronic anal fissure"],"prefix":"10.1111","volume":"9","author":[{"given":"H. A.","family":"Elwakeel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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