{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T16:03:30Z","timestamp":1758125010675},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,3,3]],"date-time":"2008-03-03T00:00:00Z","timestamp":1204502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> To determine the minimum family history of colorectal cancer (CRC), which justifies colonoscopy and to establish whether further colonic assessment is necessary after a negative screening colonoscopy.<\/jats:p><jats:p><jats:bold>Method\u2002<\/jats:bold> A retrospective review of every colonoscopy undertaken for family screening at the Royal Berkshire and Battle Hospitals, Reading between October 1996 and July 2004.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Four hundred and thirty\u2010two patients (261 women) with an average age of 48\u2003years (range 14\u201384) were screened. Three cancers in patients over the age of 60\u2003years and 49 adenomas were found in 37 patients. Twenty three of 281 (8%) patients with a \u2018low\u2010risk\u2019 family history (one in 12 or less lifetime risk of developing CRC) had either a cancer or an adenoma. Eighteen of 151 (12%) patients with a \u2018high\u2010risk\u2019 family history (one in 10 or greater) had a similar positive colonoscopy. Thirteen of 15 patients who had an adenoma aged under 45\u2003years had a high\u2010risk family history. Seventy\u2010three patients subsequently underwent two or more follow\u2010up colonoscopies. There were 22 adenomatous polyps found in 12 patients (16%) at the first screening, nine adenomas in seven patients in the second colonoscopy and four adenomas found in four patients in all subsequent colonoscopies.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Patients with a low\u2010risk family history have a similar adenoma pick\u2010up to that of the general population. These patients need not be screened below the age of 50 unless symptomatic. Follow up of low\u2010risk family history (FH) patients with a negative screening colonoscopy is unlikely to be beneficial.<\/jats:p>","DOI":"10.1111\/j.1463-1318.2007.01441.x","type":"journal-article","created":{"date-parts":[[2008,3,3]],"date-time":"2008-03-03T23:37:58Z","timestamp":1204587478000},"page":"506-511","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Colonoscopy for screening and follow up of patients with a family history of colorectal cancer"],"prefix":"10.1111","volume":"10","author":[{"given":"M. G.","family":"Tytherleigh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. V.","family":"Ng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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