{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:30:20Z","timestamp":1790116220183,"version":"4.0.1"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,2,7]],"date-time":"2012-02-07T00:00:00Z","timestamp":1328572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim\u00a0<\/jats:bold> Crohn\u2019s disease is a chronic inflammatory condition that has been associated with high rates of mental illness. Perianal lesions are prevalent; however, their specific impact on depression has not been studied. The aim of our study was to investigate the prevalence and associations of self\u2010reported depressive symptoms in the subset of Crohn\u2019s patients with perianal disease.<\/jats:p><jats:p><jats:bold>Method\u00a0<\/jats:bold> Patients with perianal Crohn\u2019s disease from one institution were surveyed to elicit the frequency of self\u2010reported depressive symptoms. Patients completed a questionnaire and consented to medical records audit.<\/jats:p><jats:p><jats:bold>Results\u00a0<\/jats:bold> Of the 130 patients invited, 69 (53%) returned a survey. Depressive symptoms were self\u2010reported at very high rates, with 73% reporting feeling depressed and 13% reporting feeling suicidal at some point. Associations were found between depressive symptoms and duration of disease, prior surgery, past or present stoma, and anal stenosis. Patients who self\u2010reported depressive symptoms had lower overall utilities, and were willing to trade very significant proportions (upwards of 15%) of their life expectancy for disease cure.<\/jats:p><jats:p><jats:bold>Conclusion\u00a0<\/jats:bold> This study suggests that many patients with perianal Crohn\u2019s disease experience significant emotional distress that impairs their overall quality of life. Further controlled studies are required to assess the impact of perianal disease and to address the need to target interventions to meet the mental health needs of this population.<\/jats:p>","DOI":"10.1111\/j.1463-1318.2011.02613.x","type":"journal-article","created":{"date-parts":[[2011,3,17]],"date-time":"2011-03-17T15:02:37Z","timestamp":1300374157000},"page":"331-335","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Self\u2010reported depressive symptoms and suicidal feelings in perianal Crohn\u2019s disease"],"prefix":"10.1111","volume":"14","author":[{"given":"Srihari","family":"Mahadev","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane M.","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warwick","family":"Selby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Solomon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2,7]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2007.07.152"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4613"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003840050051"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199501000-00008"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20873"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05842.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.09.027"},{"key":"e_1_2_7_9_2","first-page":"A14","article-title":"The vital link between chronic disease and depressive disorders","volume":"2","author":"Chapman DP","year":"2005","journal-title":"Prev Chronic Dis"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(03)00273-7"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.8.1904"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/35.9.879"},{"key":"e_1_2_7_13_2","first-page":"PH101","article-title":"Psychological distress in Brazilian Crohn\u2019s disease patients: screening, prevalence, and risk factors","volume":"15","author":"Brandi MT","year":"2009","journal-title":"Med Sci Monit"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.28.12.1600"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05636.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.3780030405"},{"key":"e_1_2_7_17_2","first-page":"MR000008","article-title":"Methods to increase response rates to postal questionnaires","volume":"3","author":"Edwards P","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-006-0847-0"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1463-1318.2011.02613.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1463-1318.2011.02613.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:15:52Z","timestamp":1697415352000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1463-1318.2011.02613.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,7]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.1111\/j.1463-1318.2011.02613.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1463-1318.2011.02613.x","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,7]]},"assertion":[{"value":"2012-02-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}