{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T18:38:16Z","timestamp":1776710296896,"version":"3.51.2"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,3,5]],"date-time":"2012-03-05T00:00:00Z","timestamp":1330905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim\u2002<\/jats:bold> The aim of the study was to determine the impact of primary full\u2010thickness transanal excision (TAE) on the morbidity rate following radical rectal resection for cancer.<\/jats:p><jats:p><jats:bold>Method\u2002<\/jats:bold> Fourteen consecutive patients underwent radical resection for lower third rectal cancer following full\u2010thickness TAE without closure of the defect. They were compared with 25 matched patients from a prospective database of 275 rectal resections who had undergone radical resection without previous TAE for lower third rectal cancer (control group). The confounding factors were: age, sex, body mass index (BMI), classification according to the American Society of Anaesthesiologists, administration of neoadjuvant radiotherapy before rectal resection, tumour stage and type of surgical procedure.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> There were no deaths. Overall morbidity was 64.3% in the TAE group and 32% in the control group (<jats:italic>P<\/jats:italic>\u2003=\u20030.112). Surgical complications were significantly more frequent in the former (57.1%<jats:italic>vs<\/jats:italic> 20%; <jats:italic>P<\/jats:italic>\u2003=\u20030.048). The frequency of specific surgical site complications, including anastomotic complications and pelvic abscess formation requiring surgical drainage, was significantly higher in the TAE group than in the control group (42.8%<jats:italic>vs<\/jats:italic> 8%; <jats:italic>P<\/jats:italic>\u2003=\u20030.032). In univariate analysis, the only factors associated with specific surgical site complications were BMI\u2003&gt;\u200327 and TAE before rectal resection.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> This case\u2010matched study suggests that previous full\u2010thickness TAE increases the risk of surgical complications after radical resection for lower third rectal cancer, including anastomotic dehiscence and pelvic sepsis.<\/jats:p>","DOI":"10.1111\/j.1463-1318.2011.02671.x","type":"journal-article","created":{"date-parts":[[2011,5,16]],"date-time":"2011-05-16T16:14:53Z","timestamp":1305562493000},"page":"445-452","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Previous transanal full\u2010thickness excision increases the morbidity of radical resection for rectal 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