{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:35:38Z","timestamp":1759541738148,"version":"3.40.3"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2011,8,17]],"date-time":"2011-08-17T00:00:00Z","timestamp":1313539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim\u2002<\/jats:bold> Anal pain may occur in the absence of demonstrable anal pathology. Spasm of the sphincter muscles has been suggested as a cause in some patients. We aimed to assess the effectiveness of injection of botulinum toxin in treating this condition.<\/jats:p><jats:p><jats:bold>Method\u2002<\/jats:bold> Patients who had injection of botulinum toxin over a 3\u2010year period were identified retrospectively. Patients were excluded if anal fissure or other organic pathology was found to account for their symptoms on examination under anaesthetic. Long\u2010term outcome was assessed at a minimum 3\u2010year post\u2010procedure telephone follow up.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Fourteen (eight male) patients were identified, of median age 50\u2003years. Botulinum toxin (20\u2013200\u2003u) was injected into the internal sphincter. Seven of the 14 patients reported significant improvement in symptoms at 3\u2003months. Seven were available for a structured telephone review at a median of 59 (42\u201368) months. The four patients who had benefited from the injection had remained asymptomatic.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Injection of botulinum toxin into the internal anal sphincter has a role in alleviating symptoms in a small proportion of patients with functional anal pain.<\/jats:p>","DOI":"10.1111\/j.1463-1318.2011.02684.x","type":"journal-article","created":{"date-parts":[[2011,5,31]],"date-time":"2011-05-31T05:13:21Z","timestamp":1306818801000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Long\u2010term outcome of the use of botulinum toxin injection for functional anal pain"],"prefix":"10.1111","volume":"13","author":[{"given":"J. R. F.","family":"Hollingshead","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. 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