{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T04:01:27Z","timestamp":1743998487875,"version":"3.40.3"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2011,8,17]],"date-time":"2011-08-17T00:00:00Z","timestamp":1313539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim\u2002<\/jats:bold> According to the revised Bethesda Guidelines, colorectal cancer (CRC) occurring under age 50\u2003years should be screened to exclude Lynch syndrome. However, in current practice in East Anglia, tumour screening is initiated only after genetics referral, reserved for those with a strong pedigree. This study aimed to determine how many patients with young\u2010onset CRC undergo tumour screening in hospitals in East Anglia.<\/jats:p><jats:p><jats:bold>Method\u2002<\/jats:bold> A retrospective case notes review over 5\u2003years in four hospitals was undertaken to determine what proportion of those with young\u2010onset CRC underwent referral for tumour screening and to assess local practices in terms of patient counselling and management.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> One hundred and twenty\u2010two patients were included. There was an average yearly caseload of 6\u20139 patients per hospital. Documented family history was rare, as was counselling concerning metachronous and extra\u2010colonic tumour risk and CRC risk in relatives. The rate of referral for genetic testing varied from 44% to 65%. Postoperative colonoscopic surveillance was inconsistent.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Many patients with young\u2010onset CRC are managed as sporadic cancers, without Lynch syndrome having been excluded. This may have implications for survival of patients and any affected relatives. A streamlined management algorithm for tumour screening and genetics referral is recommended.<\/jats:p>","DOI":"10.1111\/j.1463-1318.2011.02685.x","type":"journal-article","created":{"date-parts":[[2011,5,31]],"date-time":"2011-05-31T05:14:24Z","timestamp":1306818864000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Management of young onset colorectal cancer: divergent practice in the East of England"],"prefix":"10.1111","volume":"13","author":[{"given":"L.","family":"Anning","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Koo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Neely","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Wells","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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