{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T20:44:11Z","timestamp":1774385051990,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,5,9]],"date-time":"2012-05-09T00:00:00Z","timestamp":1336521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim\u2002<\/jats:bold> Comparison of functional and surgical outcome of the J\u2010pouch with the side\u2010to\u2010end coloanal anastomosis after preoperative radiotherapy and total mesorectal excision in rectal cancer patients.<\/jats:p><jats:p><jats:bold>Method\u2002<\/jats:bold> In a multicentre study, patients with a carcinoma of the lower two\u2010thirds of the rectum were randomized to either a J\u2010pouch or a side\u2010to\u2010end reconstruction. Primary outcome was function of the neorectum 1\u2003year after surgery. A functional outcome [COloREctal Functional Outcome (COREFO)] questionnaire, and two quality of life questionnaires (EORTC\u2010QLQ\u2010CR38 and SF\u201036) were to be completed by all participants preoperatively, and 4 and 12\u2003months postoperatively. Independent data managers recorded surgical outcome. A group size of 30 patients in each group was calculated based on a 15\u2010point difference of the COREFO scale.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> In total, 107 patients were randomized, 55 in the J\u2010pouch group and 52 in the side\u2010to\u2010end anastomosis group. The COREFO incontinence scale at 4\u2003months and the total functional outcome at 4 and 12\u2003months showed better results for the J\u2010pouch group in comparison with the side\u2010to\u2010end anastomosis group. The remaining COREFO scales (frequency, social impact, stool\u2010related aspects and bowel medication), surgical outcome (complications, reoperations, length of hospital stay, readmissions and mortality) and quality of life did not show significant differences between treatment groups.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> The overall results of a coloanal J\u2010pouch and a side\u2010to\u2010end anastomosis are comparable, although functional results are slightly better with a J\u2010pouch. The side\u2010to\u2010end anastomosis is technically less demanding and therefore a justified alternative in sphincter\u2010saving surgery.<\/jats:p>","DOI":"10.1111\/j.1463-1318.2011.02725.x","type":"journal-article","created":{"date-parts":[[2011,8,11]],"date-time":"2011-08-11T07:51:34Z","timestamp":1313049094000},"page":"705-713","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["J\u2010pouch <i>vs<\/i> side\u2010to\u2010end coloanal anastomosis after preoperative radiotherapy and total mesorectal excision for rectal cancer: a multicentre randomized trial"],"prefix":"10.1111","volume":"14","author":[{"given":"A.","family":"Doeksen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Bakx","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Vincent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. 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