{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T06:17:08Z","timestamp":1768889828038,"version":"3.49.0"},"reference-count":9,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,3,30]],"date-time":"2012-03-30T00:00:00Z","timestamp":1333065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2012,5]]},"abstract":"Abstract<\/jats:title>Aim\u2002<\/jats:bold> In a randomized double\u2010blind study the therapeutic effect of a novel zinc\u2013aluminium ointment was compared with placebo in patients with faecal incontinence.<\/jats:p>Method\u2002<\/jats:bold> A randomized double\u2010blind trial was performed. Patients who met the inclusion criteria were randomized to receive the ointment or a placebo. All were evaluated prior to and 3\u2003weeks after ointment application, using the Wexner incontinence score and the Fecal Incontinence Quality of Life (FIQL) score.<\/jats:p>Results\u2002<\/jats:bold> Fifty patients were randomized and six were lost to follow\u2010up, leaving 24 in the treatment and 20 in the placebo group. The average ages were 61.3 and 60.7\u2003years. The respective Wexner scores prior to intervention were 16.6 and 16.7. They decreased significantly after treatment to 8.5 and 13.1 (P\u2003<\/jats:italic><\u2003<\/jats:italic>0.001 and P\u2003<\/jats:italic>=\u2003<\/jats:italic>0.002 respectively). There was a significant difference in the final scores, favouring the treatment group (P\u2003<\/jats:italic>=\u2003<\/jats:italic>0.001). The FIQL scores for the treatment group were also significantly better in all parameters compared with those of the placebo group.<\/jats:p>Conclusion\u2002<\/jats:bold> The study shows that the zinc\u2013aluminium based ointment decreases faecal incontinence significantly compared with placebo.<\/jats:p>","DOI":"10.1111\/j.1463-1318.2011.02728.x","type":"journal-article","created":{"date-parts":[[2011,7,24]],"date-time":"2011-07-24T11:21:25Z","timestamp":1311506485000},"page":"596-598","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["New treatment for faecal incontinence using zinc\u2013aluminium ointment: a double\u2010blind randomized trial"],"prefix":"10.1111","volume":"14","author":[{"given":"G.","family":"Pinedo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J.","family":"Zarate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Inostroza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Meneses","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Falloux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Molina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. E.","family":"Molina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Bellolio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Z\u00fa\u00f1iga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,3,30]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/30.6.503"},{"key":"e_1_2_7_3_2","first-page":"867","article-title":"Prevalence of fecal incontinence in health centers and nursing home residents","volume":"136","author":"Z\u00e1rate AJ","year":"2008","journal-title":"Rev Med Chil"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2000.01306.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00372964"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:NEPH.0000008797.67295.f5"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2008.01624.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02050307"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-006-0514-5"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02237236"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1463-1318.2011.02728.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1463-1318.2011.02728.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T10:53:29Z","timestamp":1743936809000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1463-1318.2011.02728.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,30]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.1111\/j.1463-1318.2011.02728.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1463-1318.2011.02728.x","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,30]]},"assertion":[{"value":"2012-03-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}