{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T14:19:50Z","timestamp":1792333190789,"version":"4.4.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,12,7]],"date-time":"2011-12-07T00:00:00Z","timestamp":1323216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim\u2002<\/jats:bold> The long\u2010term recurrence rate of fibrin glue treatment was analysed in patients with trans\u2010sphincteric cryptoglandular fistula operated by a two\u2010phase procedure: (i) fistulectomy with seton placement; (ii) fibrin sealant (Tissucol Duo\u00ae, Baxter) insertion in the track.<\/jats:p><jats:p><jats:bold>Method\u2002<\/jats:bold> Clinical data were collected prospectively for all patients operated between 2004 and 2010. The statistical association of clinical variables and recurrence was analysed and a disease\u2010free curve was constructed using the Kaplan\u2013Meier method.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Twenty\u2010eight consecutive patients (mean age 48.3\u2003\u00b1\u200313.3\u2003years; 22 men) were enrolled in the study. Middle and high trans\u2010sphincteric fistulae were diagnosed in 20 (71.4%) and eight (28.6%) patients. Seven (25%) had secondary track formation. The mean interval between the first operation and the fibrin sealant treatment was 12.5\u2003\u00b1\u20037.6\u2003months. There were no complications related to the procedure. Nine (32.1%, 95% CI 17.9\u201350.7%) patients developed recurrence between 3 and 27\u2003months after fibrin sealant treatment. Disease\u2010free curves showed that the highest probability of recurrence occurred in the first 2\u2003years. No incontinence was found at a mean follow\u2010up of 20.6 (3\u201360)\u2003months among the 67.8% patients with no evidence of recurrence.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Fibrin sealant is safe and simple. The healing rate is satisfactory without the risk of incontinence.<\/jats:p>","DOI":"10.1111\/j.1463-1318.2011.02747.x","type":"journal-article","created":{"date-parts":[[2011,8,5]],"date-time":"2011-08-05T17:50:06Z","timestamp":1312566606000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Long\u2010term results of surgery plus fibrin sealant for anal fistula"],"prefix":"10.1111","volume":"14","author":[{"given":"J.","family":"de Oca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Mill\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Golda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Biondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,7]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-005-0204-7"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02234135"},{"key":"e_1_2_7_4_2","first-page":"136","article-title":"Fibrin glue in perianal fistulas. 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