{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:43:39Z","timestamp":1787762619171,"version":"build-2784847793"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,6,8]],"date-time":"2012-06-08T00:00:00Z","timestamp":1339113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim\u2002<\/jats:bold> Patients undergoing major open surgery who have an indexed oxygen delivery (DO<jats:sub>2<\/jats:sub>I) &gt;\u2003600\u2003ml\/min\/m<jats:sup>2<\/jats:sup> have been shown to have a lower incidence of morbidity and mortality compared with those whose DO<jats:sub>2<\/jats:sub>I is below this level. Laparoscopy and Trendelenburg positioning cause a reduction in DO<jats:sub>2<\/jats:sub>I. We aimed to quantify the effect of the type of analgesia on DO<jats:sub>2<\/jats:sub>I and to correlate the DO<jats:sub>2<\/jats:sub>I achieved with the incidence of anastomotic leakage in patients undergoing laparoscopic surgery.<\/jats:p><jats:p><jats:bold>Method\u2002<\/jats:bold> Following ethical approval, patients were randomized to receive spinal anaesthesia (Group S), epidural analgesia (Group E) or intravenous morphine (Group P) followed by postoperative patient\u2010controlled analgesia (PCA). In addition to standard monitoring, oesophageal Doppler monitoring of the stroke volume allowed directed intravenous fluid therapy. The mean DO<jats:sub>2<\/jats:sub>I was compared with the anastomotic leakage rate.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Seventy\u2010five patients were recruited (Group S, 27; Group E, 23; Group P, 25). The mean (range) DO<jats:sub>2<\/jats:sub>I for all patients was 490 (230\u2010750) ml\/min\/m<jats:sup>2<\/jats:sup>. The analgesic modality had no effect on DO<jats:sub>2<\/jats:sub>I. Of the 18 patients with a DO<jats:sub>2<\/jats:sub>I of &lt;\u2003400\u2003ml\/min\/m<jats:sup>2<\/jats:sup>, four (22%) developed anastomotic leakage compared with one (%) of the 57 patients with a DO<jats:sub>2<\/jats:sub>I of &gt;\u2003400\u2003ml\/min\/m<jats:sup>2<\/jats:sup> (<jats:italic>P<\/jats:italic>\u2003=\u20030.01).<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> The analgesic modality used had no effect on the DO<jats:sub>2<\/jats:sub>I achieved. Anastomotic leakage was significantly higher in patients with a DO<jats:sub>2<\/jats:sub>I of &lt;\u2003400\u2003ml\/min\/m<jats:sup>2<\/jats:sup>. A further study assessing the outcome after raising the DO<jats:sub>2<\/jats:sub>I with inotropes is required.<\/jats:p>","DOI":"10.1111\/j.1463-1318.2011.02805.x","type":"journal-article","created":{"date-parts":[[2011,9,4]],"date-time":"2011-09-04T02:24:38Z","timestamp":1315103078000},"page":"887-892","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Intra\u2010operative oxygen delivery in infusion volume\u2010optimized patients undergoing laparoscopic colorectal surgery within an enhanced recovery programme: the effect of different analgesic modalities"],"prefix":"10.1111","volume":"14","author":[{"given":"B. F.","family":"Levy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. J.","family":"Fawcett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J. P.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. A.","family":"Rockall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,8]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.94.6.1176"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1993.03510220055034"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.318.7191.1099"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-002-1257-y"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31816a091b"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aei223"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7113.909"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/88.1.65"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200210000-00012"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2044.2002.02708.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5454"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004649900993"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/78.5.515"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2004.06.007"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sle.0000191631.66505.4a"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-007-9424-5"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31817f2c1a"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2005.02.002"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeg245"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1463-1318.2011.02805.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1463-1318.2011.02805.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T22:16:12Z","timestamp":1697408172000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1463-1318.2011.02805.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,8]]},"references-count":19,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1111\/j.1463-1318.2011.02805.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1463-1318.2011.02805.x","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,8]]},"assertion":[{"value":"2012-06-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}