{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:17:42Z","timestamp":1762323462148},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,2,7]],"date-time":"2012-02-07T00:00:00Z","timestamp":1328572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim\u2002<\/jats:bold> The study aimed to understand better the somatic mutations in the human MutL Homolog 1 (<jats:italic>hMLH1<\/jats:italic>) and human MutS Homolog 2 (<jats:italic>hMSH2<\/jats:italic>) genes in colorectal cancer (CRC) and to investigate the differences derived from ethnicity, family history, detection method and microsatellite instability (MSI).<\/jats:p><jats:p><jats:bold>Method\u2002<\/jats:bold> The terms \u2018<jats:italic>hMSH2<\/jats:italic>\u2019 or \u2018<jats:italic>hMLH1<\/jats:italic>\u2019<jats:italic>and<\/jats:italic>\u2018colorectal cancer\u2019\u2018colorectal carcinoma\u2019 or \u2018colorectal tumour\u2019 were searched in the PubMed, Springer, Lippincott, Williams &amp; Wilkins and HighWire Press databases for the publication period December 1993 to September 2010. The Comprehensive Meta Analysis V2 software (Biostat Inc.) was used to explore the prevalence and 95% confidence intervals.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The prevalence of somatic mutations in the <jats:italic>hMLH1<\/jats:italic> and <jats:italic>hMSH2<\/jats:italic> genes in CRC was 0.15 (95% CI 0.10\u20130.22) and 0.10 (95% CI 0.07\u20130.16), respectively. A higher prevalence of somatic mutations in <jats:italic>hMSH2<\/jats:italic> was found in hereditary non\u2010polyposis CRC than in sporadic CRC: 0.36 (95% CI 0.14\u20130.67) and 0.10 (95% CI 0.07\u20130.13) respectively. In addition, a higher prevalence of somatic mutations in the <jats:italic>hMLH1<\/jats:italic> gene was observed relative to <jats:italic>hMSH2<\/jats:italic> in the European group. The prevalence was higher in the high\u2010level instability (MSI\u2010H) group than in both the low\u2010level instability (MSI\u2010L) and the microsatellite stable (MSS) groups.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Somatic mutations in the <jats:italic>hMLH1<\/jats:italic> and <jats:italic>hMSH2<\/jats:italic> genes play a vital role in CRC and a high prevalence was found in this meta\u2010analysis. Furthermore, more studies are needed which focus on somatic mutations in the American population and in patients with MSI\u2010L and MSS.<\/jats:p>","DOI":"10.1111\/j.1463-1318.2011.02858.x","type":"journal-article","created":{"date-parts":[[2011,10,11]],"date-time":"2011-10-11T17:45:02Z","timestamp":1318355102000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A meta\u2010analysis of the prevalence of somatic mutations in the <i>hMLH1<\/i> and <i>hMSH2<\/i> genes in colorectal 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