{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:15:32Z","timestamp":1760955332506},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,6,8]],"date-time":"2012-06-08T00:00:00Z","timestamp":1339113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim\u2002<\/jats:bold> Chronic radiation proctitis with bleeding is a common problem encountered following radiotherapy for pelvic malignancy. Sucralfate\u2010steroid enema and formalin dab are two common nonsurgical treatments. A randomized trial was conducted to compare the efficacy of these two methods.<\/jats:p><jats:p><jats:bold>Method\u2002<\/jats:bold> This was a prospective randomized controlled trial conducted in the Jawaharlal Institute of Postgraduate Medical Education &amp; Research (JIPMER) from August 2005 to May 2007. One\u2010hundred and two patients with chronic radiation proctitis, presenting as rectal bleeding after radiotherapy for carcinoma of the cervix, were recruited and randomly allocated into two treatment groups: Group 1, formalin dab; and Group 2, sucralfate\u2010steroid retention enema. The mean age of the patients was 51.3\u2003\u00b1\u20035.1\u2003years. The mean interval between the end of radiotherapy and the onset of bleeding was 12.3 \u2003\u00b1\u20033.5\u2003months. Symptom score and sigmoidoscopic grade were assessed before, and at 1\u2003month after, treatment.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Ninety per cent of patients in Group 1 and 74.5% of patients in Group 2 responded to treatment (<jats:italic>P<\/jats:italic>\u2003=\u20030.038). In spite of having a higher median symptom score before treatment, patients in Group 1 demonstrated a marked decrease in symptom score after treatment compared with patients in Group 2 and the difference once again was statistically significant (<jats:italic>P<\/jats:italic>\u2003=\u20030.000). Similarly, the median sigmoidoscopic grade was significantly lower for patients in Group 1 compared with patients in Group 2 after treatment (<jats:italic>P<\/jats:italic>\u2003=\u20030.000). There were no specific treatment\u2010related complications in either group.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Formalin (4%) dab is superior to sucralfate\u2010steroid retention enema for treatment of chronic haemorrhagic radiation proctitis.<\/jats:p>","DOI":"10.1111\/j.1463-1318.2012.03008.x","type":"journal-article","created":{"date-parts":[[2012,2,22]],"date-time":"2012-02-22T19:21:11Z","timestamp":1329938471000},"page":"876-882","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Formalin dab, the effective way of treating haemorrhagic radiation proctitis: a randomized trial from a tertiary care hospital in South India"],"prefix":"10.1111","volume":"14","author":[{"given":"V. P.","family":"Nelamangala Ramakrishnaiah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. D.","family":"Javali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Dharanipragada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. S.","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Krishnamachari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,6,8]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(16)46138-4"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600360"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02238241"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-6614-1"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-005-0030-z"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-006-0707-y"},{"key":"e_1_2_6_8_2","first-page":"42","article-title":"Accuracy and reliability of the endoscopic classification of chronic radiation\u2010induced proctopathy using a novel grading method","volume":"39","author":"Chi KD","year":"2005","journal-title":"J Clin Gastroenterol"},{"key":"e_1_2_6_9_2","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD003455","article-title":"Non surgical intervention for late radiation proctitis in patients who have received radical radiotherapy to the pelvis","author":"Denton AS","year":"2002","journal-title":"Cochrane Database of systemic review"},{"key":"e_1_2_6_10_2","first-page":"315","article-title":"Radiation proctitis: a decade\u2019s experience","volume":"51","author":"Wong MT","year":"2010","journal-title":"Singapore Med J"},{"key":"e_1_2_6_11_2","unstructured":"Senthil KumarR VivekanandanS AjithSahaiet\u00a0al.Prospective randomised double blind controlled trial to compare rectal sucralfate\u2010steroid combination enema and short chain fatty acid enema in patients with radiation induced proctosigmoiditis. A dissertation submitted to Pondicherry University in partial fulfillment of the requirement for the award of the degree of M.S. Surgery. 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