{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T16:46:44Z","timestamp":1768927604509,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,8,22]],"date-time":"2012-08-22T00:00:00Z","timestamp":1345593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim\u2002<\/jats:bold> Using a high\u2010resolution 3D endoanal ultrasound, we have observed that some perianal fistulas show a hypoechogenic fistula tract surrounded by a well\u2010defined hyperechogenic area with a thin hypoechogenic edge in patients with Crohn\u2019s disease [\u2018Crohn\u2019s Ultrasound Fistula Sign\u2019 (CUFS)], unlike conventional fistula tracks. The study aimed to determine the prevalence of CUFS in a consecutive series of patients with anal fistula.<\/jats:p><jats:p><jats:bold>Method\u2002<\/jats:bold> Of 157 patients (median age 45, range 14\u201386\u2003years, 100 males) with perianal fistula were examined with 3D endoanal ultrasound. All 3D volumes were stored and analysed retrospectively by two independent observers blinded to the clinical information of the patients.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> There were 29 patients with Crohn\u2019s disease of whom 20 (69%) showed CUFS. CUFS was absent in 125 (98%) of 128 patients without Crohn\u2019s disease. The positive and negative predictive value of CUFS for Crohn\u2019s disease was 87% and 93%, respectively. The kappa value of the two independent observers was 0.77, indicating a substantial interobserver agreement.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> This study provides a new 3D endoanal ultrasound criterion, CUFS, of perianal fistula in patients with Crohn\u2019s disease. The sign can be used to discriminate a Crohn\u2019s from other types of fistula, which may be useful in the management of patients with anal fistula.<\/jats:p>","DOI":"10.1111\/j.1463-1318.2012.03047.x","type":"journal-article","created":{"date-parts":[[2012,4,16]],"date-time":"2012-04-16T16:15:46Z","timestamp":1334592946000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["A unique 3D endoanal ultrasound feature of perianal Crohn\u2019s fistula: the \u2018Crohn ultrasound fistula sign\u2019"],"prefix":"10.1111","volume":"14","author":[{"given":"A.","family":"Zawadzki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Starck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bohe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Thorlacius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,8,22]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7599.2007.00242.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21261"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02603444"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/014107687807100904"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181da1db8"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.06.079"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.12.019"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.32362"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(02)80131-1"},{"key":"e_1_2_7_11_2","first-page":"5","article-title":"Epidemiology of inflammatory bowel disease","volume":"78","author":"Jayanthi V","year":"1991","journal-title":"Q J Med"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastro.2003.08.024"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.28676"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004230000183"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02247.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-008-0424-8"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20826"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.1999.01020.x"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2333031724"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-011-0719-z"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1463-1318.2012.03047.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1463-1318.2012.03047.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T05:21:56Z","timestamp":1698729716000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1463-1318.2012.03047.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,22]]},"references-count":19,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.1111\/j.1463-1318.2012.03047.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1463-1318.2012.03047.x","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,22]]},"assertion":[{"value":"2012-08-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}