{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:04:40Z","timestamp":1761894280679,"version":"build-2065373602"},"reference-count":72,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,4,25]],"date-time":"2006-04-25T00:00:00Z","timestamp":1145923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:p>\n                    The influences of single\u2010gene missense mutations expressing diabetes (\n                    <jats:italic>db\/db<\/jats:italic>\n                    ), obese (\n                    <jats:italic>ob\/ob<\/jats:italic>\n                    ) or dystrophia (\n                    <jats:italic>dy\/dy<\/jats:italic>\n                    ) dysregulated metabolic syndromes on hind limb bone maturation and cytodevelopment in C57BL\/KsJ mice were evaluated by radiological, macro\u2010 and cytomorphometric analysis of the resulting variances in os coxae, femur and tibia osteodevelopment indices relative to control parameters between 8 and 16 weeks of age. Associated with obesity and hyperglycaemic\/hyperinsulinaemic states, both\n                    <jats:italic>db\/db<\/jats:italic>\n                    and\n                    <jats:italic>ob\/ob<\/jats:italic>\n                    mutants demonstrated significant suppression of hind limb maturation (length) and cytodensity indices relative to control growth parameters. By contrast, skeletal growth suppression induced by\n                    <jats:italic>dy\/dy<\/jats:italic>\n                    mutation expression was associated with lean body mass and normoglycaemic\/hypoinsulinaemic systemic endometabolic indices. In both\n                    <jats:italic>db\/db<\/jats:italic>\n                    and\n                    <jats:italic>ob\/ob<\/jats:italic>\n                    mutation syndromes, osteovascular, \u2010interstitial and \u2010cytolipidaemia were prominent cytochemical aberrations of the osteopaenic states relative to the dyslipidaemia\/fibrodysplasia characteristic of\n                    <jats:italic>dy\/dy<\/jats:italic>\n                    osteomaturation. Between 8 and 16 weeks of age, both\n                    <jats:italic>ob\/ob<\/jats:italic>\n                    and\n                    <jats:italic>db\/db<\/jats:italic>\n                    groups demonstrated extensive cortical interstitial (laminal) osteolipidaemia and suppressed cytodensities compared to control indices. These data demonstrate that the abnormal hyperglycaemic\/hyperinsulinaemic endometabolic states associated with the expression of\n                    <jats:italic>db\/db<\/jats:italic>\n                    and\n                    <jats:italic>ob\/ob<\/jats:italic>\n                    genomutations promote extensive lipidaemia\u2010induced osteopaenia, compromising hind limb osteomaturation and cytodensity indices, as compared to the hyperfibritic osteopaenia characteristic of\n                    <jats:italic>dy\/dy<\/jats:italic>\n                    mutation syndromes. Recognized therapeutic modulation of the hypercytolipidaemic component of diabetes\u2013obesity syndromes may prove to be effective towards amelioration of the deleterious influences of these expressed hyperglycaemic, dysregulated lipometabolic conditions on osteomaturation and cytodevelopment.\n                  <\/jats:p>","DOI":"10.1111\/j.1463-1326.2006.00603.x","type":"journal-article","created":{"date-parts":[[2006,4,25]],"date-time":"2006-04-25T13:09:19Z","timestamp":1145970559000},"page":"311-322","source":"Crossref","is-referenced-by-count":9,"title":["Influences of diabetes (\n                    <i>db\/db<\/i>\n                    ), obese (\n                    <i>ob\/ob<\/i>\n                    ) and dystrophic (\n                    <i>dy\/dy<\/i>\n                    ) genotype mutations on hind limb bone maturation: a morphometric, radiological and cytochemical indices analysis"],"prefix":"10.1111","volume":"9","author":[{"given":"D. R.","family":"Garris","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. M.","family":"Burkemper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. L.","family":"Garris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,4,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(97)00029-X"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2002-220072"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197601292940502"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(00)00426-9"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(88)90024-5"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2004.03.011"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.140.4.6620"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.2337\/diaclin.22.1.10"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00564.2003"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(03)00169-8"},{"key":"e_1_2_6_12_2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.2337\/diab.37.1.8","article-title":"Mineral metabolism and bone mass at peripheral and axial skeleton in diabetes mellitus","volume":"37","author":"Auwerx J","year":"1988","journal-title":"Diabetes"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.37.6.702"},{"key":"e_1_2_6_14_2","first-page":"86","article-title":"Hyperlipidemia promotes osteoclastic potential of bone marrow cells ex vivo","volume":"24","author":"Tintut Y","year":"1988","journal-title":"Arterio Thromb Vasc Biol"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-123-1-290"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00429772"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-814488"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-004-0863-0"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1089\/met.2004.2.198"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-7-10"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.51.31937"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/153537020122600103"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.5.2498"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.2007.S118"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2004.12.009"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-004-1021-4"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathophys.2004.02.001"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1159\/000084115"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1996.270.2.E320"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00275183"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1081\/ERC-120025039"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1177\/153537020322800302"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-186-42625"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2003.10.001"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2004.01.001"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.1.51"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1177\/153537020322800909"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:PITU.0000044628.84041.99"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.44.7.775"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(93)90241-F"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650040114"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.7.1196"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.7.1192"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/1056-8727(94)90058-2"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1990.tb00167.x"},{"key":"e_1_2_6_46_2","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/00003086-198807000-00028","article-title":"The influence of diabetes mellitus on the healing of closed fractures","volume":"232","author":"Loder R","year":"1990","journal-title":"Clin Orthoped"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1500223"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(97)00143-9"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-6009(08)80139-0"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-108-6-2228"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-189-42783"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092110407"},{"key":"e_1_2_6_53_2","doi-asserted-by":"publisher","DOI":"10.1159\/000074420"},{"key":"e_1_2_6_54_2","doi-asserted-by":"publisher","DOI":"10.1093\/labmed\/14.12.779"},{"key":"e_1_2_6_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2004.09.012"},{"key":"e_1_2_6_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(96)00047-6"},{"key":"e_1_2_6_57_2","first-page":"193","article-title":"Studies in the diabetes mouse, IV: evaluation of glomerula lesions and associated proteinuria","volume":"66","author":"Like A","year":"1972","journal-title":"Am J Pathol"},{"key":"e_1_2_6_58_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1979.59.3.719"},{"key":"e_1_2_6_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)91037-8"},{"key":"e_1_2_6_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(90)90272-Z"},{"key":"e_1_2_6_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(84)90303-3"},{"key":"e_1_2_6_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(95)00121-S"},{"key":"e_1_2_6_63_2","doi-asserted-by":"publisher","DOI":"10.1159\/000054445"},{"key":"e_1_2_6_64_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.1988.tb01021.x"},{"key":"e_1_2_6_65_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-61-5-905"},{"key":"e_1_2_6_66_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.3.7366"},{"key":"e_1_2_6_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.06.028"},{"key":"e_1_2_6_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08827-X"},{"key":"e_1_2_6_69_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.13.1729"},{"key":"e_1_2_6_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/414813a"},{"key":"e_1_2_6_71_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.10.2083"},{"key":"e_1_2_6_72_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.42.1.118"},{"key":"e_1_2_6_73_2","doi-asserted-by":"publisher","DOI":"10.1159\/000425092"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1463-1326.2006.00603.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/j.1463-1326.2006.00603.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:26:37Z","timestamp":1761863197000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/j.1463-1326.2006.00603.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4,25]]},"references-count":72,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["10.1111\/j.1463-1326.2006.00603.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1463-1326.2006.00603.x","archive":["Portico"],"relation":{},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"type":"print","value":"1462-8902"},{"type":"electronic","value":"1463-1326"}],"subject":[],"published":{"date-parts":[[2006,4,25]]}}}