{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:10:32Z","timestamp":1789963832167,"version":"4.0.1"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,2,2]],"date-time":"2007-02-02T00:00:00Z","timestamp":1170374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:p>\n                    <jats:bold>Aim:\u2002<\/jats:bold>\n                    Intramyocellular triglyceride (IMTG) correlates with insulin resistance, but there is no clear causal relationship. Insulin resistance and associated hyperinsulinaemia may increase IMTG, via the insulin\u2010regulated transcription factor, sterol regulatory element\u2013binding protein 1 (SREBP\u20101). PPAR agonists may also affect IMTG via changes in insulin sensitivity, SREBP\u20101 or other factors.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:\u2002<\/jats:bold>\n                    We examined skeletal muscle IMTG and SREBP\u20101 expression, and metabolic parameters in Zucker diabetic fatty rats (ZDF) after 25 weeks of PPAR\u2010\u03b3 or PPAR\u2010\u03b1 administration.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:\u2002<\/jats:bold>\n                    Compared with Zucker lean rats (ZL), untreated ZDF had significantly higher weights, serum glucose, insulin, free fatty acids, total cholesterol and triglycerides. IMTG and SREBP\u20101c messenger RNA (mRNA) were also higher in untreated ZDF; both were decreased by fenofibrate (FF). Rosiglitazone (Rosi), despite marked improvement in glycaemia, hyperinsulinaemia and hyperlipidaemia, failed to affect SREBP\u20101 expression, and increased body weight and IMTG. Rosi\/FF combination caused less weight gain and no IMTG increase, despite metabolic effects similar to Rosi alone.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:\u2002<\/jats:bold>\n                    IMTG and SREBP\u20101c mRNA are high in the ZDF. FF and Rosi both improved insulin sensitivity but had opposite effects on IMTG. Thus, there was a clear discordance between insulin sensitivity and IMTG with PPAR agonists, indicating that IMTG and insulin sensitivity do not share a simple relationship.\n                  <\/jats:p>","DOI":"10.1111\/j.1463-1326.2006.00696.x","type":"journal-article","created":{"date-parts":[[2007,2,3]],"date-time":"2007-02-03T02:42:44Z","timestamp":1170470564000},"page":"714-723","source":"Crossref","is-referenced-by-count":16,"title":["Discordance between intramuscular triglyceride and insulin sensitivity in skeletal muscle of Zucker diabetic rats after treatment with fenofibrate and rosiglitazone"],"prefix":"10.1111","volume":"9","author":[{"given":"K. J.","family":"Nadeau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. B.","family":"Ehlers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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