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Recently, the receptor for niacin, GPR109A, was discovered. GPR109A in the adipocyte mediates a niacin\u2010induced inhibition of lipolysis, which could play a crucial part in its role as a lipid\u2010modifying drug. GPR109A in epidermal Langerhans cells mediates flushing, an unwanted side effect of niacin therapy. For the past decade, the functions of GPR109A have been studied and full or partial agonists have been developed in an attempt to achieve the beneficial effects of niacin while avoiding the unwanted flushing side effect. 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