{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T22:51:50Z","timestamp":1780527110188,"version":"3.54.1"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,1,18]],"date-time":"2012-01-18T00:00:00Z","timestamp":1326844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>\n                    <jats:bold>Aim:<\/jats:bold>\n                    The Sibutramine Cardiovascular OUTcomes trial showed that sibutramine produced greater mean weight loss than placebo but increased cardiovascular morbidity but not mortality. The relationship between 12\u2010month weight loss and subsequent cardiovascular outcomes is explored.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Overweight\/obese subjects (N = 10 744), \u226555 years with cardiovascular disease and\/or type 2 diabetes mellitus, received sibutramine plus weight management during a 6\u2010week Lead\u2010in Period before randomization to continue sibutramine (N = 4906) or to receive placebo (N = 4898). The primary endpoint was the time from randomization to first occurrence of a primary outcome event (non\u2010fatal myocardial infarction, non\u2010fatal stroke, resuscitated cardiac arrest or cardiovascular death).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    For the total population, mean weight change during Lead\u2010in Period (sibutramine) was \u22122.54 kg. Post\u2010randomization, mean total weight change to Month 12 was \u22124.18 kg (sibutramine) or \u22121.87 kg (placebo). Degree of weight loss during Lead\u2010in Period or through Month 12 was associated with a progressive reduction in risk for the total population in primary outcome events and cardiovascular mortality over the 5\u2010year assessment. Although more events occurred in the randomized sibutramine group, on an average, a modest weight loss of approximately 3 kg achieved in the Lead\u2010in Period appeared to offset this increased event rate. Moderate weight loss (3\u201310 kg) reduced cardiovascular deaths in those with severe, moderate or mild cardiovascular disease.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Modest weight loss over short\u2010term (6 weeks) and longer\u2010term (6\u201312 months) periods is associated with reduction in subsequent cardiovascular mortality for the following 4\u20135 years even in those with pre\u2010existing cardiovascular disease. While the sibutramine group experienced more primary outcome events than the placebo group, greater weight loss reduced overall risk of these occurring in both groups.\n                  <\/jats:p>","DOI":"10.1111\/j.1463-1326.2011.01554.x","type":"journal-article","created":{"date-parts":[[2011,12,22]],"date-time":"2011-12-22T15:26:35Z","timestamp":1324567595000},"page":"523-530","source":"Crossref","is-referenced-by-count":122,"title":["Maintained intentional weight loss reduces cardiovascular outcomes: results from the Sibutramine Cardiovascular OUTcomes (SCOUT) trial"],"prefix":"10.1111","volume":"14","author":[{"given":"I. D.","family":"Caterson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Finer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Coutinho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. F.","family":"Van Gaal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. P.","family":"Maggioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Torp\u2010Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. M.","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U. 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T.","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the SCOUT Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,18]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05487"},{"key":"e_1_2_7_3_2","unstructured":"Organization for Economic Cooperation and Development Health Data 2010.Statistics and Indicators.Available from URL:http:\/\/www.oecd.org\/document\/11\/0 3343 en_21571361_44315115_45549771_1_1_1_1 00.html. 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