{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T16:58:15Z","timestamp":1785862695450,"version":"3.56.0"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,2,20]],"date-time":"2012-02-20T00:00:00Z","timestamp":1329696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p>\n                    <jats:bold>Aims:<\/jats:bold>\n                    Amylinergic and melanocortinergic systems have each been implicated in energy balance regulation. We examined the interactive effects of both systems using gene knockout and pharmacological approaches.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Acute food consumption was measured in overnight fasted male wild\u2010type (WT) and melanocortin\u20104 receptor (MC\u20104R) deficient rats and in male and female WT and amylin knockout mice (AmyKO). Changes in food intake, body weight and composition in male WT and MC\u20104R deficient rats and in male diet\u2010induced obese (DIO) rats. Pharmacological treatments included either rat amylin, murine leptin and\/or the MC\u20104R agonist, Ac\u2010R[CEH\u2010dF\u2010RWC]\u2010amide.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Amylin (10 \u00b5g\/kg, IP) decreased food intake in WT but not in MC\u20104R deficient rats (30 and 60 min post\u2010injection). Ac\u2010R[CEH\u2010dF\u2010RWC]\u2010amide (100 \u00b5g\/kg, IP) suppressed food intake similarly in male WT and AmyKO, but was ineffective in female AmyKO. Amylin (50 \u00b5g\/kg\/day for 28 days) and leptin (125 \u00b5g\/kg\/day) synergistically reduced food intake and body weight in WT and MC\u20104R deficient rats to a similar extent. Amylin (100 \u00b5g\/kg) combined with Ac\u2010R[CEH\u2010dF\u2010RWC]\u2010amide (100 \u00b5g\/kg, IP) decreased acute food intake over 3 h to a greater extent than either agent alone in fasted mice. In DIO rats, additive anorexigenic, weight\u2010 and fat\u2010lowering effects were observed over 12 days with the combination of rat amylin (50 \u00b5g\/kg\/day) and Ac\u2010R[CEH\u2010dF\u2010RWC]\u2010amide (2.3 mg\/kg, SC injected daily).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Although amylin's acute anorexigenic effects are somewhat blunted in MC\u20104R deficiency and those of MC\u20104R agonism in amylin deficiency, these effects are surmountable with pharmacological administration lending therapeutic potential to combined amylin\/melanocortin agonism for obesity.\n                  <\/jats:p>","DOI":"10.1111\/j.1463-1326.2012.01570.x","type":"journal-article","created":{"date-parts":[[2012,1,25]],"date-time":"2012-01-25T13:25:25Z","timestamp":1327497925000},"page":"608-615","source":"Crossref","is-referenced-by-count":20,"title":["Interactions of amylinergic and melanocortinergic systems in the control of food intake and body weight in rodents"],"prefix":"10.1111","volume":"14","author":[{"given":"J. D.","family":"Roth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"D'Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. S.","family":"Griffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Athanacio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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