{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:18:11Z","timestamp":1792657091825,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,5,16]],"date-time":"2012-05-16T00:00:00Z","timestamp":1337126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p>\n                    <jats:bold>Aims:<\/jats:bold>\n                    Imeglimin is the first in a new tetrahydrotriazine\u2010containing class of oral antidiabetic agents, the glimins. It has been shown to act on the liver, muscle and pancreatic\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010cells to uniquely target the key defects of type 2 diabetes. Two studies were performed to compare the safety and efficacy of imeglimin with metformin and placebo on glycaemic control in type 2 diabetes patients.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    In a 4\u2010week phase IIa, three\u2010arm parallel group study, patients were randomized to imeglimin 2000 mg once daily (od), imeglimin 1000 mg twice daily (bid) or metformin 850 mg bid and responses to an oral glucose tolerance test (OGTT) were measured. In an 8\u2010week phase IIa, four\u2010arm controlled multi\u2010centre study, patients were randomized to imeglimin 500 mg bid, imeglimin 1500 mg bid, metformin 850 mg bid or placebo. Glycaemic assessments included area under the curve (AUC) up to 6 h (AUC\n                    <jats:sub>0\u22126h<\/jats:sub>\n                    ) for glucose during a prolonged meal, fasting plasma glucose (FPG) and HbA1c. Safety and tolerability were assessed in both studies through adverse event recording and laboratory parameters, vital signs and electrocardiogram.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Imeglimin was found to be as effective as metformin at reducing the AUC\n                    <jats:sub>PG<\/jats:sub>\n                    and AUC\n                    <jats:sub>0\u22126h<\/jats:sub>\n                    , FPG and HbA1c. Imeglimin exhibited a favourable tolerability profile in comparison to metformin.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    The results from both studies confirm that imeglimin displays a superior benefit : risk profile compared with metformin in type 2 diabetes patients. The encouraging tolerability profile of imeglimin could make it suitable for combination with other classes of antidiabetic agents and may increase availability to a wider patient population.\n                  <\/jats:p>","DOI":"10.1111\/j.1463-1326.2012.01611.x","type":"journal-article","created":{"date-parts":[[2012,4,20]],"date-time":"2012-04-20T12:14:02Z","timestamp":1334924042000},"page":"852-858","source":"Crossref","is-referenced-by-count":119,"title":["Imeglimin, a novel glimin oral antidiabetic, exhibits a good efficacy and safety profile in type 2 diabetic patients"],"prefix":"10.1111","volume":"14","author":[{"given":"V.","family":"Pirags","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Lebovitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Fouqueray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5,16]]},"reference":[{"key":"e_1_2_8_2_2","unstructured":"World Health OrganisationDiabetes Fact Sheet No. 312. January 2011. Available from URL:http:\/\/www.who.int\/mediacentre\/factsheets\/fs312\/en\/. 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