{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:55:29Z","timestamp":1773420929995,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,5,28]],"date-time":"2012-05-28T00:00:00Z","timestamp":1338163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2012,10]]},"abstract":"\n The Goto\u2010Kakizaki (\n GK<\/jats:styled-content>\n ) rat, a type 2 diabetes model, has increased pancreatic islet and white adipose tissue (\n WAT<\/jats:styled-content>\n ) blood flow, and this can be normalized by acute administration of\n SR59230A<\/jats:styled-content>\n , a \u03b2\n 3<\/jats:sub>\n \u2010adrenoceptor antagonist. We now implanted osmotic pumps which allowed a constant release of saline or\n SR59230A<\/jats:styled-content>\n (0.6 mg\/kg \u00d7 day) for 2 weeks. A decrease in islet blood flow was seen also after 2 weeks of continuous\n SR59230A<\/jats:styled-content>\n treatment in the\n GK<\/jats:styled-content>\n rat. However, no improvement in glucose tolerance was seen in the\n GK<\/jats:styled-content>\n rats. Neither did\n SR59230A<\/jats:styled-content>\n affect insulin secretion from isolated islets\n in vitro<\/jats:italic>\n .\n WAT<\/jats:styled-content>\n blood flow was not affected by the 2\u2010week\n SR59230A<\/jats:styled-content>\n treatment. Thus, the increased islet blood flow seen in the\n GK<\/jats:styled-content>\n rat can be normalized for up to 2 weeks, which opens the possibilities for further studies on the long\u2010term functional role on the islet blood flow increase in this type 2 diabetes model.\n <\/jats:p>","DOI":"10.1111\/j.1463-1326.2012.01616.x","type":"journal-article","created":{"date-parts":[[2012,5,7]],"date-time":"2012-05-07T15:06:44Z","timestamp":1336403204000},"page":"960-962","source":"Crossref","is-referenced-by-count":4,"title":["Two\u2010week treatment with the \u03b2\n 3<\/sub>\n \u2010adrenoceptor antagonist\n SR59230A<\/scp>\n normalizes the increased pancreatic islet blood flow in type 2 diabetic\n GK<\/scp>\n rats"],"prefix":"10.1111","volume":"14","author":[{"given":"U. S.","family":"Pettersson","sequence":"first","affiliation":[{"name":"Department of Medical Cell Biology Uppsala University Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Sandberg","sequence":"additional","affiliation":[{"name":"Department of Medical Cell Biology Uppsala University Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Jansson","sequence":"additional","affiliation":[{"name":"Department of Medical Cell Biology Uppsala University Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,5,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.45.4.385"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1992.262.5.E736"},{"key":"e_1_2_7_4_1","first-page":"111","article-title":"The blood flow to the pancreas and the islets of Langerhans during an intraperitoneal glucose load in the rat","volume":"1","author":"Jansson L","year":"1984","journal-title":"Diabetes Res"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(95)00802-0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(89)90182-9"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-1523"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1677\/jme.0.0270133"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.9.2620"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00140.2009"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01228134"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051322"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00722.x"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1463-1326.2012.01616.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/j.1463-1326.2012.01616.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T23:57:38Z","timestamp":1761868658000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/j.1463-1326.2012.01616.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,28]]},"references-count":12,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1111\/j.1463-1326.2012.01616.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1463-1326.2012.01616.x","archive":["Portico"],"relation":{},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,28]]}}}