{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T08:38:46Z","timestamp":1767861526674,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,6,25]],"date-time":"2012-06-25T00:00:00Z","timestamp":1340582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The effects of linagliptin on fat content in diet\u2010induced obese rats were compared with those of the appetite suppressant sibutramine. Female Wistar rats fed a high\u2010fat diet (HFD) for 3\u2009months received vehicle, linagliptin (10\u2009mg\/kg) or sibutramine (5\u2009mg\/kg) treatment orally, once daily for 6 additional weeks, while continuing the HFD. Magnetic resonance spectroscopy analysis of fat content was performed at baseline and at the end of the 6\u2010week treatment period. Linagliptin treatment profoundly reduced hepatic fat compared with vehicle, with an effect comparable to that of sibutramine. The vehicle\u2010corrected mean change (95% CI) from baseline in hepatic fat and intramyocellular lipid was \u221259.0% (\u2212104.3%, \u221213.6%; p\u2009=\u20090.015) and \u221262.1% (\u2212131.6%, 7.4%; p\u2009=\u20090.073), respectively, for linagliptin compared with \u221254.3% (\u2212101.5%, \u22127.1%; p\u2009=\u20090.027) and \u221272.4% (\u2212142.4%, \u22122.4%; p\u2009=\u20090.044), respectively, for sibutramine.<\/jats:p>","DOI":"10.1111\/j.1463-1326.2012.01629.x","type":"journal-article","created":{"date-parts":[[2012,5,31]],"date-time":"2012-05-31T10:23:44Z","timestamp":1338459824000},"page":"1050-1053","source":"Crossref","is-referenced-by-count":6,"title":["Evaluation of body fat composition after linagliptin treatment in a rat model of diet\u2010induced obesity: a magnetic resonance spectroscopy study in comparison with sibutramine"],"prefix":"10.1111","volume":"14","author":[{"given":"T.","family":"Klein","sequence":"first","affiliation":[{"name":"Department of CardioMetabolic Diseases Research Boehringer Ingelheim  Biberach Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. G.","family":"Niessen","sequence":"additional","affiliation":[{"name":"Department of CardioMetabolic Diseases Research Boehringer Ingelheim  Biberach Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Ittrich","sequence":"additional","affiliation":[{"name":"Department of CardioMetabolic Diseases Research Boehringer Ingelheim  Biberach Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Mayoux","sequence":"additional","affiliation":[{"name":"Department of CardioMetabolic Diseases Research Boehringer Ingelheim  Biberach Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.\u2010P.","family":"Mueller","sequence":"additional","affiliation":[{"name":"Medical Faculty, Department of Neurology University of Ulm  Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Cheetham","sequence":"additional","affiliation":[{"name":"RenaSci Consultancy Ltd  BioCity, Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Stiller","sequence":"additional","affiliation":[{"name":"Department of CardioMetabolic Diseases Research Boehringer Ingelheim  Biberach Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kassubek","sequence":"additional","affiliation":[{"name":"Medical Faculty, Department of Neurology University of Ulm  Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Mark","sequence":"additional","affiliation":[{"name":"Department of CardioMetabolic Diseases Research Boehringer Ingelheim  Biberach Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,6,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-011-0028-y"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.03.054"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2011.10.007"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0631828100"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/db10-1707"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1549"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801931"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmr.5610040607"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0904944106"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030723"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2011.02462.x"},{"key":"e_1_2_7_13_1","first-page":"A577","article-title":"The DPP\u20104 inhibitor linagliptin significantly improves insulin sensitivity in diet induced obese mice","volume":"59","author":"Kern M","year":"2010","journal-title":"Diabetes"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/db10-1338"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00274.2011"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1463-1326.2012.01629.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/j.1463-1326.2012.01629.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T01:00:35Z","timestamp":1761872435000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/j.1463-1326.2012.01629.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,25]]},"references-count":14,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1111\/j.1463-1326.2012.01629.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1463-1326.2012.01629.x","archive":["Portico"],"relation":{},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,25]]}}}