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Most of these genes are related to changes in \u03b2\u2010cell function, with a few associated with decreased insulin sensitivity and obesity. Interestingly, using quantitative traits based on continuous measures rather than dichotomous ones, it has become evident that not all genes associated with changes in fasting or post\u2010prandial glucose are also associated with a diagnosis of type 2 diabetes. Identification of these gene variants has provided novel insights into the physiology and pathophysiology of the \u03b2\u2010cell, including the identification of molecules involved in \u03b2\u2010cell function that were not previously recognized as playing a role in this critical cell.<\/jats:p>","DOI":"10.1111\/j.1463-1326.2012.01650.x","type":"journal-article","created":{"date-parts":[[2012,8,28]],"date-time":"2012-08-28T08:47:45Z","timestamp":1346143665000},"page":"46-56","source":"Crossref","is-referenced-by-count":19,"title":["Interactions between genetic background, insulin resistance and \u03b2\u2010cell function"],"prefix":"10.1111","volume":"14","author":[{"given":"S. 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