{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:03:24Z","timestamp":1792461804194,"version":"4.5.0"},"reference-count":95,"publisher":"Wiley","issue":"s3","license":[{"start":{"date-parts":[[2012,8,28]],"date-time":"2012-08-28T00:00:00Z","timestamp":1346112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p>\n                    Amyloid forms within pancreatic islets in type 2 diabetes from aggregates of the \u03b2\u2010cell peptide islet amyloid polypeptide (\n                    <jats:styled-content style=\"fixed-case\">IAPP<\/jats:styled-content>\n                    ). These aggregates are toxic to \u03b2\u2010cells, inducing \u03b2\u2010cell death and dysfunction, as well as inciting islet inflammation. The \u03b2\u2010cell is subject to a number of other stressors, including insulin resistance and hyperglycaemia, that may contribute to amyloid formation by increasing\n                    <jats:styled-content style=\"fixed-case\">IAPP<\/jats:styled-content>\n                    production by the \u03b2\u2010cell. \u03b2\u2010Cell dysfunction, evident as impaired glucose\u2010stimulated insulin secretion and defective prohormone processing and exacerbated by metabolic stress, is also a likely prerequisite for islet amyloid formation to occur in type 2 diabetes. Islet transplants in patients with type 1 diabetes face similar stressors, and are subject to rapid amyloid formation and impaired proinsulin processing associated with progressive loss of \u03b2\u2010cell function and mass. Declining \u03b2\u2010cell mass is predicted to increase metabolic demand on remaining \u03b2\u2010cells, promoting a feed\u2010forward cycle of \u03b2\u2010cell decline.\n                  <\/jats:p>","DOI":"10.1111\/j.1463-1326.2012.01657.x","type":"journal-article","created":{"date-parts":[[2012,8,28]],"date-time":"2012-08-28T08:47:45Z","timestamp":1346143665000},"page":"68-77","source":"Crossref","is-referenced-by-count":92,"title":["Metabolic stress,\n                    <scp>IAPP<\/scp>\n                    and islet amyloid"],"prefix":"10.1111","volume":"14","author":[{"given":"J.","family":"Montane","sequence":"first","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine University of British Columbia  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Klimek\u2010Abercrombie","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine University of British Columbia  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. J.","family":"Potter","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine University of British Columbia  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Westwell\u2010Roper","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine University of British Columbia  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bruce Verchere","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine University of British Columbia  Vancouver BC Canada"},{"name":"Department of Surgery, Child &amp; Family Research Institute University of British Columbia  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,8,28]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-0410"},{"key":"e_1_2_13_3_1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1210\/endo.143.2.8623","article-title":"Minireview: secondary beta\u2010cell failure in type 2 diabetes\u2013a convergence of glucotoxicity and lipotoxicity","volume":"143","author":"Poitout V","year":"2002","journal-title":"Endocrinology"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1546"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-009-0090-x"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-1452"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/db06-1650"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2925"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa065213"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.2.241"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200008103430607"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.1.102"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.5.5.527"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.11.3881"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(86)90708-4"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.23.8628"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00042.2009"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.02.010"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.02.036"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/368756a0"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2009.02.013"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08-0485"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002854"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1935"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2007-0037"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-010-1671-6"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00285291"},{"key":"e_1_2_13_28_1","doi-asserted-by":"crossref","first-page":"634","DOI":"10.2337\/diab.39.5.634","article-title":"Evidence of cosecretion of islet amyloid polypeptide and insulin by \u00df\u2010cells","volume":"39","author":"Kahn SE","year":"1990","journal-title":"Diabetes"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(95)01512-4"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.47.4.640"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1996.271.6.E1008"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-2019"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2000.278.6.G946"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-005-1732-4"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0320865"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-8477(02)00630-5"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1210\/mend-3-11-1775"},{"key":"e_1_2_13_38_1","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1093\/clinchem\/42.4.576","article-title":"Development of sensitive immunoassays to detect amylin and amylin\u2010like peptides in unextracted plasma","volume":"42","author":"Percy AJ","year":"1996","journal-title":"Clin Chem"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909024107"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118649"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000238677.00750.32"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.050649"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.46.11.1725"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2004-0407"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(03)00004-4"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1088\/1478-3975\/8\/6\/066009"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.2337\/db05-1566"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1110\/ps.036350.108"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2003.10.045"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)61022-1"},{"key":"e_1_2_13_51_1","first-page":"951","article-title":"Localization of the basement membrane heparan sulfate proteoglycan in islet amyloid deposits in type II diabetes mellitus","volume":"116","author":"Young ID","year":"1992","journal-title":"Arch Path Lab Med"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9861(03)00116-4"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.1989.tb01228.x"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-002-0984-5"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1600"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0295-143"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.47.4.612"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00208.2007"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008423200"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199608)179:4<443::AID-PATH612>3.0.CO;2-7"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8227(89)90008-9"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051138"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529209000092"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.9.1477"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02743276"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-200104000-00013"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.7.2117"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0206-7"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.2337\/db06-1579"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-010-1715-y"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.8.3492"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2143-3"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1093\/ilar.47.3.225"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00400803"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.47.5.743"},{"key":"e_1_2_13_76_1","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.2337\/diab.45.8.1094","article-title":"Treatment with growth hormone and dexamethasone in mice transgenic for human islet amyloid polypeptide causes islet amyloidosis and beta cell dysfunction","volume":"45","author":"Couce M","year":"1996","journal-title":"Diabetes"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00471.2004"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2338-7"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-1255-x"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2451-2"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-010-1717-9"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi702518m"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00082.2006"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1088\/1478-3975\/6\/1\/015005"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(97)90209-2"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.19.1.28"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64852-3"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.7.2235"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-979042"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.12.187"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00400722"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.3109\/2000-1967-113"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-1560"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0802893"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.1.100"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02740.x"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1463-1326.2012.01657.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/j.1463-1326.2012.01657.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:33:06Z","timestamp":1761870786000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/j.1463-1326.2012.01657.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,28]]},"references-count":95,"journal-issue":{"issue":"s3","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1111\/j.1463-1326.2012.01657.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1463-1326.2012.01657.x","archive":["Portico"],"relation":{},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,28]]}}}