{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T13:54:54Z","timestamp":1770904494727,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,8,30]],"date-time":"2012-08-30T00:00:00Z","timestamp":1346284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      Evaluate the safety and efficacy of once\u2010daily insulin detemir initiated in routine clinical practice in patients with type 2 diabetes mellitus inadequately controlled with oral hypoglycaemic agents (\n                      <jats:styled-content style=\"fixed-case\">OHAs<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This large observational study was conducted in 10 countries. Adverse event data (including hypoglycaemia) and glycaemic control were recorded before and 24\u2009weeks following insulin initiation while patients continued routine clinical management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In this study, 17\u2009374 patients (53% male) were included. Mean pre\u2010insulin values (\u00b1s.d.) were: age 62\u2009\u00b1\u200912\u2009years; body mass index (\n                      <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\n                      ) 29.3\u2009\u00b1\u20095.4\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ; diabetes duration 10\u2009\u00b1\u20097\u2009years; haemoglobin A1c (\n                      <jats:styled-content style=\"fixed-case\">HbA1c<\/jats:styled-content>\n                      ) 8.9\u2009\u00b1\u20091.6%. During the study, 27 patients experienced serious adverse drug reaction, severe hypoglycaemic events or both; and there were 31 episodes of severe hypoglycaemia in 21 patients. After 24\u2009weeks,\n                      <jats:styled-content style=\"fixed-case\">HbA1c<\/jats:styled-content>\n                      was 7.5\u2009\u00b1\u20091.2% (change of \u22121.3%; p\u2009&lt;\u20090.001) and mean weight change was \u22120.6\u2009kg (confidence interval  \u22120.7, \u22120.5\u2009kg, p\u2009&lt;\u20090.001). Daily insulin dose increased from 13\u2009\u00b1\u20096 U (0.16\u2009\u00b1\u20090.09 U\/kg) to 22\u2009\u00b1\u200916 U (0.27\u2009\u00b1\u20090.\n                      <jats:styled-content style=\"fixed-case\">17U<\/jats:styled-content>\n                      \/kg) by 24\u2009weeks. Multivariate regression analysis identified several independent demographic and treatment predictors of end of study\n                      <jats:styled-content style=\"fixed-case\">HbA1c<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Addition of once\u2010daily insulin detemir to patients with type 2 diabetes mellitus on\n                      <jats:styled-content style=\"fixed-case\">OHA<\/jats:styled-content>\n                      therapy resulted in few adverse events, significant improvements in glycaemic control, small reductions in weight and low rates of hypoglycaemia. On the basis of this study, concerns about hypoglycaemia or weight gain should not preclude initiation of basal insulin analogues in patients with poor glycaemic control on\n                      <jats:styled-content style=\"fixed-case\">OHAs<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1463-1326.2012.01665.x","type":"journal-article","created":{"date-parts":[[2012,7,25]],"date-time":"2012-07-25T13:23:19Z","timestamp":1343222599000},"page":"1129-1136","source":"Crossref","is-referenced-by-count":43,"title":["The safety and efficacy of adding once\u2010daily insulin detemir to oral hypoglycaemic agents in patients with type 2 diabetes in a clinical practice setting in 10 countries"],"prefix":"10.1111","volume":"14","author":[{"given":"K.","family":"Khunti","sequence":"first","affiliation":[{"name":"Department of Health Sciences University of Leicester  Leicester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Caputo","sequence":"additional","affiliation":[{"name":"Servizio di Diabetologia Policlinico Gemelli, Universita'Cattolica  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Damci","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism Istanbul University, Cerrahpasa Medical School  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. J.","family":"Dzida","sequence":"additional","affiliation":[{"name":"Department of Internal Diseases Medical University of Lublin  Lublin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q.","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Xijing Hospital, Fourth Military Medical University  Xian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Practice for Internal Medicine and Diabetology  Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Karnieli","sequence":"additional","affiliation":[{"name":"Endocrinology, Diabetes &amp; Metabolism Rambam Medical Center and Rappaport Faculty of Medicine, Technion  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Liebl","sequence":"additional","affiliation":[{"name":"Center for Diabetes and Metabolism, m&amp;i\u2010Fachklinik Bad Heilbrunn  Bad Heilbrunn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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