{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T21:50:16Z","timestamp":1776721816146,"version":"3.51.2"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,8,14]],"date-time":"2012-08-14T00:00:00Z","timestamp":1344902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To examine the impact of diabetes duration, chronic pancreatitis and other factors on pancreatic cancer risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective cohort study using the UK General Practice Research Database compared pancreatic cancer incidence and risk in patients with type 2 diabetes mellitus (\n                      <jats:styled-content style=\"fixed-case\">T2DM<\/jats:styled-content>\n                      ) versus patients without diabetes. Multivariate Cox regression adjusting for age, sex, history of chronic pancreatitis, gallbladder disease, obesity, smoking and alcohol use and Charlson comorbidity index was used to estimate hazard ratio (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      ) [95% confidence interval,\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      ]. Analyses were repeated using various time windows for diabetes duration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1903 incident pancreatic cancers were identified, 436 in patients with\n                      <jats:styled-content style=\"fixed-case\">T2DM<\/jats:styled-content>\n                      (78.76 per 100 000 person\u2010years [95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      : 71.54, 86.51]) and 1467 in patients without diabetes (11.46 per 100 000 person\u2010years [10.88, 12.06]). Pancreatic cancer risk was significant for\n                      <jats:styled-content style=\"fixed-case\">T2DM<\/jats:styled-content>\n                      (adjusted\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      1.80 [1.52, 2.14]), increasing age, history of chronic pancreatitis and tobacco use. For patients with chronic pancreatitis and\n                      <jats:styled-content style=\"fixed-case\">T2DM<\/jats:styled-content>\n                      , the adjusted\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      was 12.12 [6.02, 24.40]. Incidence was highest in patients with \u22655 year duration of\n                      <jats:styled-content style=\"fixed-case\">T2DM<\/jats:styled-content>\n                      . In patient populations with duration of\n                      <jats:styled-content style=\"fixed-case\">T2DM<\/jats:styled-content>\n                      ranging from \u22651 to \u22655 years, adjusted\n                      <jats:styled-content style=\"fixed-case\">HRs<\/jats:styled-content>\n                      remained significant but point estimates attenuated slightly with longer duration of\n                      <jats:styled-content style=\"fixed-case\">T2DM<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Patients with\n                      <jats:styled-content style=\"fixed-case\">T2DM<\/jats:styled-content>\n                      had an 80% increased risk of pancreatic cancer versus patients without diabetes. Patients with\n                      <jats:styled-content style=\"fixed-case\">T2DM<\/jats:styled-content>\n                      and chronic pancreatitis were 12 times more likely to develop pancreatic cancer.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1463-1326.2012.01667.x","type":"journal-article","created":{"date-parts":[[2012,7,25]],"date-time":"2012-07-25T13:22:43Z","timestamp":1343222563000},"page":"1123-1128","source":"Crossref","is-referenced-by-count":46,"title":["Impact of diabetes duration and chronic pancreatitis on the association between type 2 diabetes and pancreatic cancer risk"],"prefix":"10.1111","volume":"14","author":[{"given":"K. G.","family":"Brodovicz","sequence":"first","affiliation":[{"name":"Merck Sharp &amp; Dohme Corp.  Whitehouse Station NJ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. D.","family":"Kou","sequence":"additional","affiliation":[{"name":"Merck Sharp &amp; Dohme Corp.  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