{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:29:08Z","timestamp":1773286148872,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,9,9]],"date-time":"2012-09-09T00:00:00Z","timestamp":1347148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2013,1]]},"abstract":"Abstract<\/jats:title>\n \n Aims<\/jats:title>\n \n To investigate therapy persistence, frequency of hypoglycaemia and macrovascular outcomes among type 2 diabetes patients with dipeptidyl peptidase\u20104 (\n DPP<\/jats:styled-content>\n \u20104) inhibitors (\n DPP<\/jats:styled-content>\n \u20104) and sulphonylureas (\n SU<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Data from 19 184\n DPP<\/jats:styled-content>\n \u20104 (mean age: 64\u2009years; 56% males) and 31 110\n SU<\/jats:styled-content>\n users (69\u2009years; 51%) with new prescriptions (index date), without additional antidiabetics except metformin, in 1201 general practises in Germany were analysed. Therapy discontinuation (prescription gap >90\u2009days), hypoglycaemia [International Classification of Diseases (ICD\u201010)] and macrovascular outcomes (\n ICD<\/jats:styled-content>\n \u201010) (2\u2010year follow\u2010up) were compared adjusting for age, sex, diabetes duration, metformin, previous hypoglycaemia, health insurance, hypertension, hyperlipidaemia, antihypertensives, lipid\u2010lowering and antithrombotic drugs, microvascular complications and Charlson co\u2010morbidity score using logistic or Cox regression models.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Two years after index date,\n DDP<\/jats:styled-content>\n \u20104 (non\u2010persistence: 39%) were associated with a lower risk of discontinuation compared to\n SU<\/jats:styled-content>\n (49%) [adjusted hazard ratio (\n HR<\/jats:styled-content>\n ): 0.74; 95% confidence interval (CI): 0.71\u20130.76]. Hypoglycaemias (\u22651) were documented in 0.18% patients with\n DPP<\/jats:styled-content>\n \u20104 and in 1.00% with\n SU<\/jats:styled-content>\n [odds ratio (OR): 0.21; 95%\n CI<\/jats:styled-content>\n : 0.08\u20130.57]. Hypoglycaemias were significantly associated with incident macrovascular complications (\n HR<\/jats:styled-content>\n : 1.6; 95% CI: 1.1\u20132.2). Risk of macrovascular events was 26% lower in\n DPP<\/jats:styled-content>\n \u20104 than in\n SU<\/jats:styled-content>\n users.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Lack of persistence with antidiabetic therapy is frequently found in primary care patients.\n DPP<\/jats:styled-content>\n \u20104 was associated with lower therapy discontinuation and a fivefold reduced frequency of patients with hypoglycaemia compared to\n SU<\/jats:styled-content>\n . The low absolute numbers of hypoglycaemias are most likely due to the fact that only severe events were documented.\n DPP<\/jats:styled-content>\n \u20104 treatment was associated with reduced incidence of macrovascular events relative to\n SU<\/jats:styled-content>\n in type 2 diabetes patients in primary care practises.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/j.1463-1326.2012.01674.x","type":"journal-article","created":{"date-parts":[[2012,8,3]],"date-time":"2012-08-03T15:09:12Z","timestamp":1344006552000},"page":"55-61","source":"Crossref","is-referenced-by-count":72,"title":["Treatment persistence, hypoglycaemia and clinical outcomes in type 2 diabetes patients with dipeptidyl peptidase\u20104 inhibitors and sulphonylureas: a primary care database analysis"],"prefix":"10.1111","volume":"15","author":[{"given":"W.","family":"Rathmann","sequence":"first","affiliation":[{"name":"Institute of Biometrics and Epidemiology German Diabetes Center Dusseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Kostev","sequence":"additional","affiliation":[{"name":"IMS HEALTH Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. B.","family":"Gruenberger","sequence":"additional","affiliation":[{"name":"Novartis Pharma Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Dworak","sequence":"additional","affiliation":[{"name":"Novartis Pharma Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Bader","sequence":"additional","affiliation":[{"name":"Novartis Pharma Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Giani","sequence":"additional","affiliation":[{"name":"Institute of Biometrics and Epidemiology German Diabetes Center Dusseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-9025"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1283744"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-s229"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2011.09.028"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032412"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e1369"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-2048"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2012.03577.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-0017"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.5414\/CPP47617"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2011.228"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlr.0000182534.19832.83"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2007.01630.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2010.00761.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2010.01214.x"},{"key":"e_1_2_8_17_1","first-page":"491","article-title":"Persistence patterns with oral hypoglycemic agents in type 2 diabetes","volume":"9","author":"Stephens JM","year":"2002","journal-title":"J Clin Outcomes Manag"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.405"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2008.068197"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa066224"},{"key":"e_1_2_8_21_1","first-page":"789","article-title":"A study of the effects of hypoglycemic agents on vascular complications in patients with adult\u2010onset diabetes. 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