{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:16:43Z","timestamp":1762917403988,"version":"build-2065373602"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,9,9]],"date-time":"2012-09-09T00:00:00Z","timestamp":1347148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2013,1]]},"abstract":"\n We characterised 62 non\u2010diabetic, middle\u2010aged, Caucasians with and without the T risk allele of rs7903146 in transcription factor 7\u2010like 2 (\n \n TCF7L2<\/jats:styled-content>\n <\/jats:italic>\n ) with regard to secretion of insulin, glucagon, glucose\u2010dependent insulinotropic polypeptide (\n GIP<\/jats:styled-content>\n ), glucagon\u2010like peptide\u20101 (\n GLP<\/jats:styled-content>\n \u20101) as well as insulin sensitivity and endogenous glucose production. All participants had a 3\u2010h oral glucose tolerance test (\n OGTT<\/jats:styled-content>\n ), an intravenous glucose tolerance test and a euglycaemic, hyperinsulinaemic clamp. After adjustment for age and sex, risk T allele carriers had higher haemoglobin A1c levels (p\u2009=\u20090.030), reduced first\u2010phase insulin response (p\u2009=\u20090.048), higher peripheral insulin sensitivity (p\u2009=\u20090.050) and lower fasting\n GIP<\/jats:styled-content>\n concentrations (p\u2009=\u20090.003) than\n CC<\/jats:styled-content>\n allele carriers. The latter was also reflected by lower total\n GIP<\/jats:styled-content>\n secretion during the\n OGTT<\/jats:styled-content>\n (p\u2009=\u20090.018). We found no significant differences in endogenous glucose production, hepatic insulin sensitivity or fasting concentrations of glucose, insulin, glucagon and\n GLP<\/jats:styled-content>\n \u20101 between the groups. The findings suggest that the effect of\n \n TCF7L2<\/jats:styled-content>\n <\/jats:italic>\n on diabetes risk may include reduced secretion of\n GIP<\/jats:styled-content>\n .\n <\/jats:p>","DOI":"10.1111\/j.1463-1326.2012.01675.x","type":"journal-article","created":{"date-parts":[[2012,8,3]],"date-time":"2012-08-03T15:08:56Z","timestamp":1344006536000},"page":"91-95","source":"Crossref","is-referenced-by-count":22,"title":["Incretin and pancreatic hormone secretion in Caucasian non\u2010diabetic carriers of the\n \n TCF7L2<\/scp>\n <\/i>\n rs7903146 risk T allele"],"prefix":"10.1111","volume":"15","author":[{"given":"K.","family":"F\u00e6rch","sequence":"first","affiliation":[{"name":"Steno Diabetes Center Gentofte Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Pilgaard","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Rigshospitalet, University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. K.","family":"Knop","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine F, Gentofte Hospital University of Copenhagen Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Hansen","sequence":"additional","affiliation":[{"name":"The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences University of Copenhagen Copenhagen Denmark"},{"name":"Faculty of Health Sciences University of Southern Denmark Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences University of Copenhagen Copenhagen Denmark"},{"name":"Department of Biomedical Science University of Copenhagen Copenhagen Denmark"},{"name":"Hagedorn Research Institute Gentofte Denmark"},{"name":"Faculty of Health Sciences University of Aarhus Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences University of Southern Denmark Odense Denmark"},{"name":"Research Centre for Prevention and Health, Glostrup Hospital University of Copenhagen Glostrup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. J.","family":"Holst","sequence":"additional","affiliation":[{"name":"The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences University of Copenhagen Copenhagen Denmark"},{"name":"Department of Biomedical Science University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1960"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30706"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-1169"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1307-x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-010-1940-4"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjr.0000096541.30533.82"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-0951-x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.184028"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-007-0753-6"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0855"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2011.05.006"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-s227"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1463-1326.2012.01675.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/j.1463-1326.2012.01675.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T01:55:57Z","timestamp":1761875757000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/j.1463-1326.2012.01675.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,9]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1111\/j.1463-1326.2012.01675.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1463-1326.2012.01675.x","archive":["Portico"],"relation":{},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"type":"print","value":"1462-8902"},{"type":"electronic","value":"1463-1326"}],"subject":[],"published":{"date-parts":[[2012,9,9]]}}}