{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T19:25:13Z","timestamp":1765826713316,"version":"3.30.2"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,8,16]],"date-time":"2004-08-16T00:00:00Z","timestamp":1092614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Purpose\u2002<\/jats:bold>To evaluate the efficacy of a novel, professionally manufactured, frontal sinus valved glaucoma shunt in maintaining normal intraocular pressure (IOP) and vision in dogs with primary glaucoma.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold>Three eyes of three dogs diagnosed with primary glaucoma were included in this prospective clinical study. A Cullen frontal sinus valved glaucoma shunt was implanted into each glaucomatous globe. Dogs were treated postoperatively with topical neomycin\/polymyxin B\/0.1% dexamethasone and 0.03% flurbiprofen every 6\u00a0h tapered over 8\u201312\u00a0weeks, and meloxicam at 0.1\u00a0mg\/kg orally every 24\u00a0h for 7\u201310\u00a0days. IOP, intracameral shunt position and apparent patency, and vision were assessed twice daily for up to 4 (<jats:italic>n<\/jats:italic>= 3 eyes) and 10 (<jats:italic>n<\/jats:italic>= 2 eyes) days postoperatively, and then at re\u2010examination periods of up to 36\u00a0weeks (<jats:italic>n<\/jats:italic>= 1 eye). Postoperative complications were recorded and documented photographically.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold>Normal IOP was maintained in all shunted globes (range 10\u201329\u00a0mmHg; mean\u00a0=\u00a016.7 mmHg at 24\u00a0h; IOP\u00a0=\u00a023\u00a0mmHg at 36\u00a0weeks) postoperatively for 2\u00a0days (3\/3 eyes), 8\u00a0weeks (2\/2 eyes), and 36\u00a0weeks (1\/1 eye) without additional antiglaucoma therapies. Photopic vision and shunt position and patency were maintained in all shunted globes for all follow\u2010up periods. Postoperative complications included mild aqueous flare and fibrin (<jats:italic>n<\/jats:italic>= 3 eyes for 3\u201310\u00a0days postoperatively); intracameral shunt occlusion with fibrin (<jats:italic>n<\/jats:italic>= 1 eye at days 2 and 4); partial anterior chamber tube extrusion (<jats:italic>n<\/jats:italic>= 1 eye at day 4), and focal corneal edema (<jats:italic>n<\/jats:italic>= 1 eye at 18\u00a0weeks). Tissue plasminogen activator injected intracamerally through the silicone tube near the frontal sinus effectively resolved the fibrinous shunt occlusion.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold>The Cullen frontal sinus valved glaucoma shunt shows promise for the management of canine primary glaucoma.<\/jats:p>","DOI":"10.1111\/j.1463-5224.2004.00320.x","type":"journal-article","created":{"date-parts":[[2004,8,16]],"date-time":"2004-08-16T07:18:52Z","timestamp":1092640732000},"page":"311-318","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Cullen frontal sinus valved glaucoma shunt: preliminary findings in dogs with primary glaucoma"],"prefix":"10.1111","volume":"7","author":[{"given":"Cheryl L.","family":"Cullen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,8,16]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(1999)48:5<591::AID-JBM1>3.0.CO;2-9"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.4.306"},{"key":"e_1_2_6_4_2","first-page":"482","article-title":"Glaucoma implants: their use in difficult cases of glaucoma","volume":"98","author":"Bartholomew RS","year":"1978","journal-title":"Transactions of the Ophthalmological Society UK"},{"key":"e_1_2_6_5_2","first-page":"301","article-title":"Glaucoma","volume":"44","author":"Martin CL","year":"1977","journal-title":"American Animal Hospital Association Proceedings (Abstract)"},{"key":"e_1_2_6_6_2","first-page":"219","article-title":"Glaucoma in dogs and cats: a review of 421 cases. 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