{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T17:08:25Z","timestamp":1784567305583,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,8,16]],"date-time":"2004-08-16T00:00:00Z","timestamp":1092614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Purpose\u2002<\/jats:bold> To examine and evaluate clinical indications and postoperative outcome in a series of small animal patients in which corneal disease was managed by the application of butyl 2\u2010cyanoacrylate adhesive.<\/jats:p><jats:p><jats:bold>Materials and methods\u2002<\/jats:bold> In this retrospective study all small animal patients were identified that presented to the Royal Veterinary College, University of London over a 2\u2010year period, in which corneal disease was managed by the application of butyl 2\u2010cyanoacrylate. Indications for application, complicating factors prior to gluing, glue retention time, postoperative comfort, and extent of subsequent corneal reaction and scarring were noted for each case. Long\u2010term follow\u2010up data concerning visual and cosmetic outcome were obtained from owners and referring veterinarians.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Thirty\u2010seven patients (28 dogs and 9 cats), in which 39 eyes were treated, were identified. Indications for corneal gluing in this series included stromal ulceration (26\/39 eyes); descemetocele (4\/39 eyes); corneal laceration\/foreign body (5\/39 eyes); lamellar keratectomy (3\/39 eyes) and superficial ulceration (1\/39 eyes). At least one factor responsible for initiation, persistence or progression of the ulcer was identified in 66.7% of eyes prior to corneal gluing. These included keratomalacia; confirmed bacterial keratitis; corneal edema related to endothelial disease and keratoconjunctivitis sicca. Cyanoacrylate was generally well tolerated by patients with only 8\/34 eyes demonstrating transient blepharospasm and increased lacrimation postoperatively. Retention time of cyanoacrylate varied widely from &lt;\u00a01\u00a0week to approximately 6\u00a0months, but was &lt;\u00a02\u00a0months in the majority (89%) of eyes. Exaggerated corneal vascularization was an infrequent postoperative complication, noted in only six canine eyes, and did not appear to be related to initial corneal disease, glue retention time or breed.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Butyl 2\u2010cyanoacrylate offers a convenient, economical and effective alternative to other treatment modalities, such as conjunctival grafts, in the management of corneal defects in canine and feline patients.<\/jats:p>","DOI":"10.1111\/j.1463-5224.2004.00327.x","type":"journal-article","created":{"date-parts":[[2004,8,16]],"date-time":"2004-08-16T07:18:52Z","timestamp":1092640732000},"page":"319-326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Clinical experience with butyl\u20102\u2010cyanoacrylate adhesive in the management of canine and feline corneal disease"],"prefix":"10.1111","volume":"7","author":[{"given":"Christine M.","family":"Watt\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Elks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise L.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian J.","family":"McLellan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,8,16]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(63)92433-4"},{"key":"e_1_2_5_3_2","first-page":"439","article-title":"The role of tissue adhesive in resistant corneal ulceration and corneal melting with perforation","volume":"82","author":"Khedr SA","year":"1989","journal-title":"Bulletin of the Ophthalmological Society of Egypt"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02569064"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(93)31674-X"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(82)34649-7"},{"key":"e_1_2_5_7_2","first-page":"58","article-title":"Tissue adhesives: new perspectives in corneal perforations","volume":"10","author":"Hirst LW","year":"1979","journal-title":"Ophthalmic Surgery"},{"key":"e_1_2_5_8_2","first-page":"23","article-title":"Cyanoacrylate adhesive with conjunctival resection and superficial keratectomy in Mooren's ulcer","volume":"44","author":"Agrawal V","year":"1996","journal-title":"Indian Journal of Ophthalmology"},{"key":"e_1_2_5_9_2","first-page":"378","article-title":"Cyanoacrylate glue in the treatment of corneal ulcerations","volume":"87","author":"Golubovic S","year":"1990","journal-title":"Fortschritte der Ophthalmologie"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(80)90168-3"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)74726-9"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1968.00980050707004"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)72382-7"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-9071.2000.00351.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1970.00990030012004"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199905000-00020"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(83)34508-5"},{"key":"e_1_2_5_18_2","first-page":"197","article-title":"Clinical evaluation of cyanoacrylate glue in corneal perforations","volume":"35","author":"Bansal DC","year":"1987","journal-title":"Indian Journal of Ophthalmology"},{"key":"e_1_2_5_19_2","first-page":"671","volume-title":"Textbook of Ocular Pharmacology.","author":"John GR","year":"1997"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1970.00990040344014"},{"key":"e_1_2_5_21_2","first-page":"3","article-title":"Ocular tolerance to cyanoacrylate monomer tissue adhesive analogues","volume":"9","author":"Gasset AR","year":"1970","journal-title":"Investigative Ophthalmology"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1968.00980050647013"},{"key":"e_1_2_5_23_2","unstructured":"KenyonKR BermanM HanninenL.Tissue adhesive prevents ulceration and inhibits inflammation in the thermal\u2010burned rabbit cornea. 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