{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T23:23:34Z","timestamp":1777332214285,"version":"3.51.4"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,8,16]],"date-time":"2004-08-16T00:00:00Z","timestamp":1092614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective of this study was to describe the clinical, histologic and immunohistochemical features, the surgical treatment, and outcome of a cataract secondary to persistent hyperplastic tunica vasculosa lentis\/persistent hyperplastic primary vitreous (PHTVL\/PHPV) in a dog. A 4\u2010month\u2010old male Bloodhound dog presented for evaluation of a cataract. A complete ophthalmic examination and ocular ultrasonography were performed. A resorbing cataract with intralenticular hemorrhage, lens induced uveitis, and PHTVL\/PHPV were diagnosed. Extracapsular cataract extraction using phacoemulsification was performed. A primary posterior capsulectomy was performed to remove a retrolental plaque with the posterior capsule; the excised plaque was submitted for histopathology and immunohistochemical staining. A 41\u2010Diopter intraocular lens (IOL) was implanted. Functional vision was maintained postoperatively during the 21\u2010month follow\u2010up period. Histologically, the posterior capsule was coiled and exhibited duplication. The retrolental plaque was comprised of dense fibrous connective tissue, blood vessels, free red blood cells, hemosiderin\u2010laden macrophages, a pocket of neural tissue and numerous perivascular mast cells. With immunohistochemical staining, the neural elements were determined to be glial cells compatible with astrocytes. Cataract secondary to PHTVL\/PHPV can be successfully treated using phacoemulsification and planned posterior capsulectomy. Posterior lens capsule duplication, mast cells and astrocytic glial cells may be normal components of the fibrovascular retrolental plaque associated with PHTVL\/PHPV.<\/jats:p>","DOI":"10.1111\/j.1463-5224.2004.04032.x","type":"journal-article","created":{"date-parts":[[2004,8,16]],"date-time":"2004-08-16T07:18:52Z","timestamp":1092640732000},"page":"369-375","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Surgical management and histologic and immunohistochemical features of a cataract and retrolental plaque secondary to persistent hyperplastic tunica vasculosa lentis\/persistent hyperplastic primary vitreous (PHTVL\/PHPV) in a Bloodhound puppy"],"prefix":"10.1111","volume":"7","author":[{"given":"Anne J.","family":"Gemensky\u2010Metzler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Wilkie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,8,16]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"739","article-title":"Persistent hyperplastic tunica vasculosa lentis and persistent hyperplastic primary vitreous (PHTVL\/PHPV) in 90 closely related Doberman Pinschers: clinical aspects","volume":"16","author":"Stades FC","year":"1980","journal-title":"Journal of the American Animal Hospital Association"},{"key":"e_1_2_7_3_2","first-page":"957","article-title":"Persistent hyperplastic tunical vasculosa lentis and persistent hyperplastic primary vitreous in Doberman Pinschers: genetic aspects","volume":"19","author":"Stades FC","year":"1983","journal-title":"Journal of the American Animal Hospital Association"},{"key":"e_1_2_7_4_2","first-page":"1076","article-title":"Early morphogenesis of persistent hyperplastic tunica vasculosa lentis and primary vitreous. 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