{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:46:02Z","timestamp":1788781562953,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,10,27]],"date-time":"2004-10-27T00:00:00Z","timestamp":1098835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Animal studied\u2002<\/jats:bold> A tumor of the left eye with involvement of the brain and kidney was diagnosed in a 4\u2010year\u2010old Neapolitan mastiff.<\/jats:p><jats:p><jats:bold>Procedure\u2002<\/jats:bold> The dog presented with acute glaucoma of the left eye. Peripheral corneal vascularization and severe corneal edema obscured examination of deeper structures. Because of concurrent progressive neurologic signs the dog was euthanized and a postmortem examination was performed. The eyes, brain and samples from the lung, heart, liver and kidneys were fixed in 4% neutral buffered formalin and embedded in paraffin wax. Sections were examined by light microscopy including histochemical and immunohistochemical staining.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The ocular tumor originated from the ciliary body and was composed of small islets and cords of poorly differentiated, oval to polyhedral cells surrounded by abundant ground substance. Areas with chondroid differentiation were observed. Rosettes were not found. Metastases with the same morphology were present in the brain and in one kidney.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> An intraocular malignant teratoid medulloepithelioma with metastases to the brain and kidney is presented.<\/jats:p>","DOI":"10.1111\/j.1463-5224.2004.04054.x","type":"journal-article","created":{"date-parts":[[2004,10,27]],"date-time":"2004-10-27T09:35:46Z","timestamp":1098869746000},"page":"407-411","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Malignant teratoid medulloepithelioma with brain and kidney involvement in a dog"],"prefix":"10.1111","volume":"7","author":[{"given":"Mona","family":"Aleksandersen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Bjerk\u00e5s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reidun","family":"Heiene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Heegaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,27]]},"reference":[{"key":"e_1_2_4_2_2","first-page":"357","volume-title":"Veterinary Ophthalmology","author":"Collins KMCP","year":"1991"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.1998.00046.x"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-057133-1.50012-6"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1983.tb00376.x"},{"key":"e_1_2_4_6_2","first-page":"2449","volume-title":"Ackerman's Surgical Pathology","author":"Rosai J","year":"1996"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1997.01100150760012"},{"key":"e_1_2_4_8_2","first-page":"588","article-title":"Medullo\u2010epithelioma of the iris and ciliary body in a horse","volume":"64","author":"Bistner SI","year":"1974","journal-title":"Cornell Veterinarian"},{"key":"e_1_2_4_9_2","doi-asserted-by":"crossref","unstructured":"RiisRC ScherliePHJr RebhunWC.Intraocular medulloepithelioma in a horse.Equine Veterinary Journal Supplement1990 66\u201368.","DOI":"10.1111\/j.2042-3306.1990.tb04715.x"},{"key":"e_1_2_4_10_2","first-page":"301","article-title":"Malignant teratoid medulloepithelioma in a horse","volume":"190","author":"Szymanski CM","year":"1987","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1993.tb03017.x"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/030098587601300102"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/030098587601300504"},{"key":"e_1_2_4_14_2","first-page":"617","article-title":"Malignant intraocular medulloepithelioma in a dog","volume":"16","author":"Wilcock BP","year":"1980","journal-title":"Journal of the American Animal Hospital Association"},{"key":"e_1_2_4_15_2","first-page":"1105","article-title":"Malignant intraocular medulloepithelioma in two cockatiels","volume":"189","author":"Schmidt RE","year":"1986","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_4_16_2","first-page":"75","article-title":"Medulloepithelioma in a cat","volume":"32","author":"Jelinek F","year":"1996","journal-title":"Cesk-Slovensk\u00b7Patologie"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/030098587801500207"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1354\/vp.37-6-680"},{"key":"e_1_2_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)77739-6"},{"key":"e_1_2_4_20_2","first-page":"114","article-title":"The remarkable polymorphism of tumours of the ciliary epithelium","volume":"2","author":"Zimmerman LE","year":"1970","journal-title":"Transactions of the Australian College of Ophthalmologists"},{"key":"e_1_2_4_21_2","first-page":"13","volume-title":"Immunohistochemical Staining Methods. 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