{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T15:05:55Z","timestamp":1782227155803,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,8,16]],"date-time":"2004-08-16T00:00:00Z","timestamp":1092614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:p><jats:bold>Abstract<\/jats:bold><jats:bold> Objective\u2002<\/jats:bold> To evaluate the efficacy of using a porcine small intestinal submucosa (SIS) graft covered by a conjunctival flap for the surgical repair of full\u2010thickness corneal wounds in dogs, cats and horses.<\/jats:p><jats:p><jats:bold>Procedure\u2002<\/jats:bold> All records dating from August 1999 to February 2003 from Purdue University Veterinary Teaching Hospital of patients that had undergone ophthalmic surgical procedures and received a SIS corneal graft for a full\u2010thickness lesion were reviewed. Fifteen cases were identified including six dogs, two cats and seven horses. Requirements for inclusion in this study were that SIS was used as a corneal graft in a full\u2010thickness corneal defect and that the graft was completely covered with a conjunctival flap.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Of the 15 cases, one canine patient had received SIS following removal of an epibulbar melanocytoma. The remaining five canine patients had undergone this surgical procedure for the repair of corneal perforation. The two feline patients had been presented for corneal perforation following chronic ulceration. One equine patient had been presented for a deep melting ulcer, three for stromal corneal abscesses, and three for corneal perforations. Complications encountered postoperatively included aqueous leakage, conjunctival flap dehiscence, synechia, cataract and fibrin in the anterior chamber. Fourteen out of 15 patients were visual at the final re\u2010evaluation.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> SIS is an inexpensive, easy\u2010to\u2010handle biomaterial that appears to be suitable for the repair of full\u2010thickness corneal wounds in dogs, cats and horses. Results of our study support the conclusion that this relatively new product is an effective alternative to traditional implantation materials utilized in veterinary ophthalmology.<\/jats:p>","DOI":"10.1111\/j.1463-5224.2004.04055.x","type":"journal-article","created":{"date-parts":[[2004,8,16]],"date-time":"2004-08-16T07:18:52Z","timestamp":1092640732000},"page":"352-359","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":86,"title":["The use of porcine small intestinal submucosa for the repair of full\u2010thickness corneal defects in dogs, cats and horses"],"prefix":"10.1111","volume":"7","author":[{"given":"Martin","family":"Bussieres","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheryl G.","family":"Krohne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Stiles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy M.","family":"Townsend","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,8,16]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"641","article-title":"Conjunctival pedicle grafting in the treatment of corneal ulcers in the dog and cat","volume":"23","author":"Hakanson NE","year":"1987","journal-title":"Journal of the American Animal Hospital Association"},{"key":"e_1_2_5_3_2","first-page":"69","article-title":"Tarsoconjunctival island graft for the treatment of deep corneal ulcers, desmetocoeles, and perforations in 35 dogs and 6 cats","volume":"3","author":"Scagliotti RH","year":"1988","journal-title":"Seminars in Veterinary Medicine and Surgery (Small Animals)"},{"key":"e_1_2_5_4_2","first-page":"387","article-title":"Tarsoconjunctival pedicle graft for deep corneal ulceration in the dog and cat","volume":"13","author":"Peiffer RL","year":"1977","journal-title":"Journal of the American Animal Hospital Association"},{"key":"e_1_2_5_5_2","first-page":"270","article-title":"Lamellar corneal\u2010scleral transposition","volume":"9","author":"Parshall CJ","year":"1973","journal-title":"Journal of the American Animal Hospital Association"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(97)50104-5"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.1999.00084.x"},{"key":"e_1_2_5_8_2","first-page":"3","article-title":"Surgery of the canine and feline orbit, adnexa and globe part 6: surgery of the cornea","volume":"7","author":"Peiffer RL","year":"1987","journal-title":"Companion Animal Practice"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1990.tb04216.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1999.tb03094.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.2001.00192.x"},{"key":"e_1_2_5_12_2","first-page":"27","article-title":"Clinical and histologic features of corneal repair with porcine small intestinal submucosal grafting (Abstract)","author":"Aquino S","year":"2002","journal-title":"33rd Annual Meeting of the American College of Veterinary Ophthalmologists"},{"key":"e_1_2_5_13_2","first-page":"297","volume-title":"Veterinary Ophthalmology","author":"Regnier A","year":"1999"},{"key":"e_1_2_5_14_2","first-page":"597","article-title":"Preliminary evaluation of the biocompatibility of the small intestinal submucosa (SIS) biomaterial with the rabbit cornea","volume":"152","author":"Griguer F","year":"2001","journal-title":"Revue M\u00e9decine V\u00e9t\u00e9rinaire"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.146.5.136"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4644(19971215)67:4<478::AID-JCB6>3.0.CO;2-P"},{"key":"e_1_2_5_17_2","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/978-1-4615-8186-4_17","volume-title":"Tissue Engineering: Current Perspective.","author":"Badylak SF","year":"1993"},{"key":"e_1_2_5_18_2","first-page":"460","article-title":"The assembly and placement of ocular lavage systems in the horse","volume":"87","author":"Schoster J","year":"1992","journal-title":"Veterinary Medicine"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.1998.00026.x"},{"key":"e_1_2_5_20_2","volume-title":"Small Animal Ophthalmic Surgery: Practical Techniques for the Veterinarian","author":"Gelatt KN","year":"2001"},{"key":"e_1_2_5_21_2","first-page":"387","article-title":"Frozen corneal grafts in dogs and cats: a report on 19 cases","volume":"27","author":"Hacker DV","year":"1991","journal-title":"Journal of the American Animal Hospital Association"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1080\/00480169.1988.35486"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199509000-00006"},{"key":"e_1_2_5_24_2","first-page":"213","article-title":"Surgical management of corneal perforation with expanded polytetrafluoroethylene (Gore\u2010Tex)","volume":"22","author":"Legeais JM","year":"1991","journal-title":"Ophthalmic Surgery"},{"key":"e_1_2_5_25_2","first-page":"307","article-title":"Using conjunctival flaps to prevent rupture of deep corneal ulcers","volume":"3","author":"Schoster J","year":"1989","journal-title":"Veterinary Medicine"},{"key":"e_1_2_5_26_2","first-page":"19","article-title":"Therapeutic penetrating keratoplasty for deep corneal stromal abscesses in eight horses","volume":"7","author":"Whittaker CJG","year":"1997","journal-title":"Veterinary and Comparative Ophthalmology"},{"key":"e_1_2_5_27_2","first-page":"355","volume-title":"Veterinary Ophthalmology.","author":"Peiffer RL","year":"1999"},{"key":"e_1_2_5_28_2","first-page":"686","article-title":"Canine ulcerative keratitis","volume":"7","author":"Nasisse MP","year":"1985","journal-title":"The Compendium of Continuing Education for the Practicing Veterinarian"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.1999.00052.x"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.2001.00187.x"},{"key":"e_1_2_5_31_2","first-page":"195","article-title":"Bioactive FGF\u20102 in sterilized extracellular matrix","volume":"13","author":"Hodde J","year":"2001","journal-title":"Wounds"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.1996.2.209"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.1998.4.75"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.3109\/08941939309141619"},{"key":"e_1_2_5_35_2","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1055\/s-0038-1633133","article-title":"Small intestine submucosa as an intra\u2010articular ligamentous graft material: a pilot study in dogs","volume":"7","author":"Aiken S","year":"1994","journal-title":"Veterinary and Comparative Orthopedics and Traumatology"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1089\/end.1994.8.125"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-199510000-00008"},{"key":"e_1_2_5_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(94)70073-7"},{"key":"e_1_2_5_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(99)80227-1"},{"key":"e_1_2_5_40_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-199510000-00009"}],"container-title":["Veterinary Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1463-5224.2004.04055.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1463-5224.2004.04055.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T23:07:14Z","timestamp":1696892834000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1463-5224.2004.04055.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8,16]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["10.1111\/j.1463-5224.2004.04055.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1463-5224.2004.04055.x","archive":["Portico"],"relation":{},"ISSN":["1463-5216","1463-5224"],"issn-type":[{"value":"1463-5216","type":"print"},{"value":"1463-5224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,8,16]]},"assertion":[{"value":"2004-08-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}