{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T07:05:52Z","timestamp":1793171152431,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,9,21]],"date-time":"2005-09-21T00:00:00Z","timestamp":1127260800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives\u2002<\/jats:bold>(1) To document tear film break\u2010up time (TFBUT) in a group of cats with conjunctivitis; (2) to determine if TFBUTs from cats with conjunctivitis vary significantly from previously established normal values for TFBUT in young cats without ocular disease; (3) to determine if a correlation exists between Schirmer tear test (STT) values and TFBUTs in cats with conjunctivitis; (4) to determine if the TFBUTs in cats with conjunctivitis are influenced by the detection of DNA from feline herpes virus\u2010type 1 (FHV\u20101),<jats:italic>Chlamydophila felis<\/jats:italic>,<jats:italic>Mycoplasma<\/jats:italic>spp., and feline calicivirus.<\/jats:p><jats:p><jats:bold>Animals studied\u2002<\/jats:bold>Fourteen cats between the ages of 0.8\u00a0years to 12\u00a0years with active, untreated conjunctivitis and without active keratitis or other ocular or systemic abnormalities were included in this study.<\/jats:p><jats:p><jats:bold>Procedures\u2002<\/jats:bold>Complete ophthalmic examinations, including TFBUT, were performed on all cats. Polymerase chain reaction (PCR) screening for FHV\u20101,<jats:italic>Chlamydophila felis<\/jats:italic>,<jats:italic>Mycoplasma<\/jats:italic>spp., and feline calicivirus was performed on conjunctival swabs from affected eyes and blood samples from all cats.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold>Mean TFBUT for cats in this study was 8.9 (\u00b1\u00a04.8)\u00a0s in the right eye (OD) and 8.1 (\u00b1\u00a04.6)\u00a0s in the left eye (OS). No correlation existed between mean TFBUTs and mean STT values OD or OS. Conjunctival swabs from seven cats (<jats:italic>n<\/jats:italic>\u00a0=\u00a09 eyes) tested positive via PCR for one of the above infectious agents. Blood samples from nine cats tested positive for FHV\u20101. Mean TFBUTs for cats from which the DNA from FHV\u20101 was isolated from the blood were significantly lower than mean TFBUTs for cats from which no such DNA was isolated from the blood.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold>In this study, the mean TFBUT in cats with conjunctivitis was significantly lower than previously established values for clinically healthy cats. This supports the theory that qualitative tear film deficiency, and thus tear film instability, may play a role in the pathogenesis of feline conjunctivitis. Qualitative tear film deficiency may predispose to the development of conjunctivitis or may occur secondarily to this condition.<\/jats:p>","DOI":"10.1111\/j.1463-5224.2005.00403.x","type":"journal-article","created":{"date-parts":[[2005,9,21]],"date-time":"2005-09-21T14:59:40Z","timestamp":1127314780000},"page":"305-310","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Schirmer tear test values and tear film break\u2010up times in cats with conjunctivitis"],"prefix":"10.1111","volume":"8","author":[{"given":"Christine C.","family":"Lim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl 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